My research group aims to develop resources and tools to improve drug discovery by leveraging human data and human iPSC brain models. We work on pain/migraine, Alzheimer's disease and autism/epilepsy.
I am also active clinically and work as a Consultant Neurologist at the John Radcliffe Hospital with an interest in Headache Disorders. I am Director of the Oxford Headache Centre and developed the Oxford Community Headache Service.
I studied Medicine at the University of Birmingham (1991-97) and continued my general medical training in Oxford. I then spent three years working on the genetic linkage and association of neurological disorders at the Wellcome Trust Centre for Human Genetics. After obtaining my DPhil in 2003, I completed my training in Clinical Neurology at Oxford. I joined the Department of Physiology, Anatomy and Genetics in 2007 after being awarded an MRC Clinician Scientist Fellowship to establish my own research group. I then led IMI StemBANCC - an large public-private partnerhsip funded by the EU to establish iPSC resources for academia and industry across europe.
I now lead IMI IM2PACT which is an ambitious research programme to investigate disease mechanism involving the brain neurovascular unit and find transport mechanisms to get therapeutics into the brain.