Publications

 

Changes in iPSC-Astrocyte Morphology Reflect Alzheimer's Disease Patient Clinical Markers

Rowland HA, Miller G, Liu Q, Li S, Sharp NR, Ng B, Wei T, Arunasalam K, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Kocagoncu E, Lawson J, Malhotra P, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Zetterberg H, Cader MZ, Wade-Martins R, Lovestone S, Nevado-Holgado A, Kormilitzin A, Buckley NJ

December 2024 | Journal article | Stem Cells | Read

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Safety and Efficacy of the Blood-Stage Malaria Vaccine RH5.1/Matrix-M in Burkina Faso: Interim Results of a Double-blind, Randomised, Controlled, Phase 2b Trial in Children

Natama HM, Salkeld J, Somé A, Soremekun S, Diallo S, Traoré O, Rouamba T, Ouédraogo F, Ouédraogo E, Daboné KCS, Koné NA, Compaoré ZMJ, Kafando M, Bonko MDA, Konaté F, Sorgho H, Nielsen CM, Pipini D, Diouf A, King LDW, Shaligram U, Long CA, Cho JS, Lawrie AM, Skinner K, Roberts R, Miura K, Bradley J, Silk SE, Draper SJ, Tinto H, Minassian AM

December 2024 | Journal article | The Lancet Infectious Diseases | Read

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Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo-PISA

Thanapongpibul C, Rifaie-Graham O, Ojansivu M, Najer A, Kim H, Bakker SE, Chami M, Peeler DJ, Liu C, Yeow J, Stevens MM

December 2024 | Journal article | Advanced Materials | Read

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Structure and Mechanism of the Zorya Anti-Phage Defense System

Hu H, Popp PF, Hughes TCD, Roa-Eguiara A, Rutbeek NR, Martin FJO, Hendriks IA, Payne LJ, Yan Y, Humolli D, Klein-Sousa V, Songailiene I, Wang Y, Nielsen ML, Berry RM, Harms A, Erhardt M, Jackson SA, Taylor NMI

December 2024 | Journal article | Nature | Read

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Structural Insights into the High Basal Activity and Inverse Agonism of the Orphan Receptor GPR6 Implicated in Parkinson's Disease

Barekatain M, Johansson LC, Lam JH, Chang H, Sadybekov AV, Han GW, Russo J, Bliesath J, Brice NL, Carlton MBL, Saikatendu KS, Sun H, Murphy ST, Monenschein H, Schiffer HH, Popov P, Lutomski CA, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V

December 2024 | Journal article | Science Signaling | Read

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Transfer Learning Bayesian Optimization for Competitor DNA Molecule Design for Use in Diagnostic Assays

Sedgwick R, Goertz JP, Stevens MM, Misener R, van der Wilk M

December 2024 | Journal article | Biotechnology and Bioengineering | Read

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Investigating the Role of Elastin and Extracellular Matrix Damage in Cardiovascular Calcification

Radvar E, Mehta K, D'Ambrosio A, Mastroianni G, Al-Jawad M, Stevens MM, Mata A, Elsharkawy S

December 2024 | Journal article | Journal of Structural Biology | Read

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Molecular Tags for Electron Cryo-Tomography

Silvester E, Baker LA

December 2024 | Journal article | Emerging Topics in Life Sciences | Read

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Rhythmic Liver Drives Feeding Behavior

Martinez-Sanchez N, Ray D

November 2024 | Journal article | Science | Read

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The PIK3CA Gene and its Pivotal Role in Tumor Tropism of Triple-Negative Breast Cancer

Mallick S, Duttaroy AK, Dutta S

November 2024 | Journal article | Science Direct | Read

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How Clavulanic Acid Inhibits Serine β-Lactamases

Lang PA, de Munnik M, Oluwole AO, Claridge TDW, Robinson CV, Brem J, Schofield CJ

November 2024 | Journal article | ChemBioChem | Read

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Hyperspectral Unmixing for Raman Spectroscopy via Physics-Constrained Autoencoders

Georgiev D, Fernández-Galiana Á, Vilms Pedersen S, Papadopoulos G, Xie R, Stevens MM, Barahona M

November 2024 | Journal article | PNAS | Read

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Non-Invasive In Vivo Sensing of Bacterial Implant Infection Using Catalytically-Optimised Gold Nanocluster-Loaded Liposomes for Urinary Readout

Chen K, Najer A, Charchar P, Saunders C, Thanapongpibul C, Klöckner A, Chami M, Peeler DJ, Silva I, Panariello L, Karu K, Loynachan CN, Frenette LC, Potter M, Tregoning JS, Parkin IP, Edwards AM, Clarke TB, Yarovsky I, Stevens MM

November 2024 | Journal article | Nature Communications | Read

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Atomically Resolved Imaging of the Conformations and Adsorption Geometries of Individual β-cyclodextrins with Non-Contact AFM

Grabarics M, Mallada B, Edalatmanesh S, Jiménez-Martín A, Pykal M, Ondráček M, Kührová P, Struwe WB, Banáš P, Rauschenbach S, Jelínek P, de la Torre B

November 2024 | Journal article | Nature Communications | Read

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Elevated Cerebrospinal Fluid Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers

Dellar ER, Vendrell I, Amein B, Lester DG, Edmond EC, Yoganathan K, Dharmadasa T, Sogorb-Esteve A, Fischer R, Talbot K, Rohrer JD, Turner MR, Thompson AG

November 2024 | Journal article | Annals of Neurology | Read

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Author Correction: Location and Function of TDP-43 in Platelets, Alterations in Neurodegenerative Diseases and Arising Considerations for Current Plasma Biobank Protocols

Luthi-Carter R, Cappelli S, Le Roux-Bourdieu M, Tentillier N, Quinn JP, Petrozziello T, Gopalakrishnan L, Sethi P, Choudhary H, Bartolini G, Gebara E, Stuani C, Font L, An J, Ortega V, Sage J, Kosa E, Trombetta BA, Simeone R, Seredenina T, Afroz T, Berry JD, Arnold SE, Carlyle BC, Adolfsson O, Sadri-Vakili G, Buratti E, Bowser R, Agbas A

November 2024 | Journal article | Scientific Reports | Read

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Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation

Pérez de la Lastra Aranda C, Tosat-Bitrián C, Porras G, Dafinca R, Muñoz-Torrero D, Talbot K, Martín-Requero Á, Martínez A, Palomo V

November 2024 | Journal article | ACS Chemical Neuroscience | Read

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Bioactive Coatings on 3D Printed Scaffolds for Bone Regeneration: Use of Laponite® to Deliver BMP-2 in an Ovine Femoral Condyle Defect Model

Marshall KM, McLaren JS, Wojciechowski JP, Callens SJP, Echalier C, Kanczler JM, Rose FRAJ, Stevens MM, Dawson JI, Oreffo ROC

November 2024 | Journal article | Science Direct | Read

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Architecture-Driven Quantitative Nanoscopy Maps Cytoskeleton Remodeling

Liu W, Yao Y, Meng J, Qian S, Han Y, Zhou L, Wang T, Chen Y, Chen L, Ye Z, Xu L, Zhang M, Qiu J, Han T, Liu X, Kuang C, Ding Z, Liu Z

October 2024 | Journal article | PNAS | Read

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Structural Basis for Antibiotic Transport and Inhibition in PepT2

Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S

October 2024 | Journal article | Nature Communications | Read

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Transfer Learning Bayesian Optimization for Competitor DNA Molecule Design for Use in Diagnostic Assays

Sedgwick R, Goertz JP, Stevens MM, Misener R, van der Wilk M

October 2024 | Journal article | Biotechnology and Bioengineering | Read

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Hyperspectral Unmixing for Raman Spectroscopy via Physics-Constrained Autoencoders

Georgiev D, Fernández-Galiana Á, Vilms Pedersen S, Papadopoulos G, Xie R, Stevens MM, Barahona M

October 2024 | Journal article | PNAS | Read

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Blood-Stage Malaria Vaccine Candidate RH5.1/Matrix-M in Healthy Tanzanian Adults and Children; An Open-Label, Non-Randomised, First-in-Human, Single-Centre, Phase 1b Trial

Silk SE, Kalinga WF, Salkeld J, Mtaka IM, Ahmed S, Milando F, Diouf A, Bundi CK, Balige N, Hassan O, Mkindi CG, Rwezaula S, Athumani T, Mswata S, Lilolime NS, Simon B, Msami H, Mohamed M, David DM, Mohammed L, Nyaulingo G, Mwalimu B, Juma O, Mwamlima TG, Sasamalo IA, Mkumbange RP, Kamage JJ, Barrett JR, King LDW, Hou MM, Pulido D, Carnrot C, Lawrie AM, Cowan RE, Nugent FL, Roberts R, Cho JS, Long CA, Nielsen CM, Miura K, Draper SJ, Olotu AI, Minassian AM

October 2024 | Journal article | Lancet Infectious Diseases | Read

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Structure and Conformation Determine Gas-Phase Infrared Spectra of Detergents

Kirschbaum C, Greis K, Gewinner S, Schöllkopf W, Meijer G, von Helden G, Pagel K, Urner LH

October 2024 | Journal article | Chem Plus Chem | Read

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A Bioorthogonal Precision Tool for Human N-Acetylglucosaminyltransferase V

Liu Y, Bineva-Todd G, Meek RW, Mazo L, Piniello B, Moroz O, Burnap SA, Begum N, Ohara A, Roustan C, Tomita S, Kjaer S, Polizzi K, Struwe WB, Rovira C, Davies GJ, Schumann B

October 2024 | Journal article | Journal of the American Chemical Society | Read

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Oligomerization-Driven Avidity Correlates with SARS-CoV-2 Cellular Binding and Inhibition

Asor R, Olerinyova A, Burnap SA, Kushwah MS, Soltermann F, Rudden LSP, Hensen M, Vasiljevic S, Brun J, Hill M, Chang L, Dejnirattisai W, Supasa P, Mongkolsapaya J, Zhou D, Stuart DI, Screaton GR, Degiacomi MT, Zitzmann N, Benesch JLP, Struwe WB, Kukura P

October 2024 | Journal article | PNAS | Read

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Lipopeptide Antibiotics Disrupt Interactions of Undecaprenyl Phosphate with UptA

Oluwole AO, Kalmankar NV, Guida M, Bennett JL, Poce G, Bolla JR, Robinson CV

October 2024 | Journal article | PNAS | Read

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Rational Structure-Guided Design of a Blood Stage Malaria Vaccine Immunogen Presenting a Single Epitope from PfRH5

Harrison TE, Alam N, Farrell B, Quinkert D, Lias AM, King LDW, Barfod LK, Draper SJ, Campeotto I, Higgins MK

October 2024 | Journal article | EMBO Molecular Medicine | Read

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Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation

Pérez de la Lastra Aranda C, Tosat-Bitrián C, Porras G, Dafinca R, Muñoz-Torrero D, Talbot K, Martín-Requero Á, Martínez A, Palomo V

October 2024 | Journal article | ACS Chemical Neuroscience | Read

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Rapid Identification of Bacterial Isolates Using Microfluidic Adaptive Channels and Multiplexed Fluorescence Microscopy

Chatzimichail S, Turner P, Feehily C, Farrar A, Crook D, Andersson M, Oakley S, Barrett L, El Sayyed H, Kyropoulos J, Nellåker C, Stoesser N, Kapanidis AN

October 2024 | Journal article | Lab on a Chip | Read

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Coupling and Activation of the β1 Adrenergic Receptor - The Role of the Third Intracellular Loop

Qiu X, Chao K, Song S, Wang YQ, Chen YA, Rouse SL, Yen HY, Robinson CV

October 2024 | Journal article | Journal of the American Chemical Society | Read

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Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo-PISA

Thanapongpibul C, Rifaie-Graham O, Ojansivu M, Najer A, Kim H, Bakker SE, Chami M, Peeler DJ, Liu C, Yeow J, Stevens MM

October 2024 | Journal article | Advanced Materials | Read

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Glial Cells Undergo Rapid Changes Following Acute Chemogenetic Manipulation of Cortical Layer 5 Projection Neurons

Vadisiute A, Meijer E, Therpurakal RN, Mueller M, Szabó F, Messore F, Jursenas A, Bredemeyer O, Krone LB, Mann E, Vyazovskiy V, Hoerder-Suabedissen A, Molnár Z

October 2024 | Journal article | Communications Biology | Read

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Bioactive Coatings on 3D Printed Scaffolds for Bone Regeneration: Use of Laponite® to Deliver BMP-2 in an Ovine Femoral Condyle Defect Model

Marshall KM, McLaren JS, Wojciechowski JP, Callens SJP, Echalier C, Kanczler JM, Rose FRAJ, Stevens MM, Dawson JI, Oreffo ROC

October 2024 | Journal article | Biomaterials Advances | Read

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Vaccine-Induced Human Monoclonal Antibodies to PfRH5 Show Broadly Neutralizing Activity Against P. falciparum Clinical Isolates

Thiam LG, McHugh K, Ba A, Li R, Guo Y, Pouye MN, Cisse A, Pipini D, Diallo F, Sene SD, Patel SD, Thiam A, Sadio BD, Mbengue A, Vigan-Womas I, Sheng Z, Shapiro L, Draper SJ, Bei AK

October 2024 | Journal article | NPJ Vaccines | Read

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Dynactin-1 Mediates Rescue of Impaired Axonal Transport due to Reduced Mitochondrial Bioenergetics in Amyotrophic Lateral Sclerosis Motor Neurons

Dafinca R, Tosat-Bitrian C, Carroll E, Vahsen BF, Gilbert-Jaramillo J, Scaber J, Feneberg E, Johnson E, Talbot K

October 2024 | Journal article | Brain Communications | Read

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Considerations of Growth Factor and Material Use in Bone Tissue Engineering Using Biodegradable Scaffolds in Vitro and in Vivo

Marshall KM, Wojciechowski JP, Jayawarna V, Hasan A, Echalier C, Øvrebø Ø, Yang T, Zhou K, Kanczler JM, Mata A, Salmeron-Sanchez M, Stevens MM, Oreffo ROC

October 2024 | Journal article | Scientific Reports | Read

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The PIK3CA Gene and its Pivotal Role in Tumor Tropism of Triple-Negative Breast Cancer

Mallick S, Duttaroy AK, Dutta S

October 2024 | Journal article | Translational Oncology | Read

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Physical-Property-Based Patterning: Simply Engineering Complex Tissues

Zlotnick HM, Stevens MM, Mauck RL

September 2024 | Journal article | Trends in Biotechnology | Read

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Natural Malaria Infection Elicits Rare but Potent Neutralizing Antibodies to the Blood-Stage Antigen RH5

Wang LT, Cooper AJR, Farrell B, Miura K, Diouf A, Müller-Sienerth N, Crosnier C, Purser L, Kirtley PJ, Maciuszek M, Barrett JR, McHugh K, Ogwang R, Tucker C, Li S, Doumbo S, Doumtabe D, Pyo CW, Skinner J, Nielsen CM, Silk SE, Kayentao K, Ongoiba A, Zhao M, Nguyen DC, Lee FE, Minassian AM, Geraghty DE, Traore B, Seder RA, Wilder BK, Crompton PD, Wright GJ, Long CA, Draper SJ, Higgins MK, Tan J

September 2024 | Journal article | Cell | Read

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Analysis Of the Diverse Antigenic Landscape of The Malaria Protein RH5 Identifies A Potent Vaccine-Induced Human Public Antibody Clonotype

Barrett JR, Pipini D, Wright ND, Cooper AJR, Gorini G, Quinkert D, Lias AM, Davies H, Rigby CA, Aleshnick M, Williams BG, Bradshaw WJ, Paterson NG, Martinson T, Kirtley P, Picard L, Wiggins CD, Donnellan FR, King LDW, Wang LT, Popplewell JF, Silk SE, de Ruiter Swain J, Skinner K, Kotraiah V, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Minassian AM, Lauffenburger DA, Miura K, Long CA, Wilder BK, Koekemoer L, Tan J, Nielsen CM, McHugh K, Draper SJ

September 2024 | Journal article | Cell | Read

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Variant-Specific Effects of GBA1 Mutations on Dopaminergic Neuron Proteostasis

Onal G, Yalçın-Çakmaklı G, Özçelik CE, Boussaad I, Şeker UÖŞ, Fernandes HJR, Demir H, Krüger R, Elibol B, Dökmeci S, Salman MM

September 2024 | Journal article | Journal of Neurochemistry | Read

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Light Sampling Behaviour Regulates Circadian Entrainment in Mice

Steel LCE, Tam SKE, Brown LA, Foster RG, Peirson SN

September 2024 | Journal article | BMC Biology | Read

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Engineering Stress as a Motivation for Filamentous Virus Morphology

McMahon A, Vijayakrishnan S, El Sayyed H, Groves D, Conley MJ, Hutchinson E, Robb NC

September 2024 | Journal article | Biophysical Reports | Read

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Blood-Stage Malaria Vaccine Candidate RH5.1/Matrix-M in Healthy Tanzanian Adults and Children; An Open-Label, Non-Randomised, First-in-Human, Single-Centre, Phase 1b Trial

Silk SE, Kalinga WF, Salkeld J, Mtaka IM, Ahmed S, Milando F, Diouf A, Bundi CK, Balige N, Hassan O, Mkindi CG, Rwezaula S, Athumani T, Mswata S, Lilolime NS, Simon B, Msami H, Mohamed M, David DM, Mohammed L, Nyaulingo G, Mwalimu B, Juma O, Mwamlima TG, Sasamalo IA, Mkumbange RP, Kamage JJ, Barrett JR, King LDW, Hou MM, Pulido D, Carnrot C, Lawrie AM, Cowan RE, Nugent FL, Roberts R, Cho JS, Long CA, Nielsen CM, Miura K, Draper SJ, Olotu AI, Minassian AM

September 2024 | Journal article | The Lancet Infectious Diseases | Read

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A Bioorthogonal Precision Tool for Human N-Acetylglucosaminyltransferase V

Liu Y, Bineva-Todd G, Meek RW, Mazo L, Piniello B, Moroz O, Burnap SA, Begum N, Ohara A, Roustan C, Tomita S, Kjaer S, Polizzi K, Struwe WB, Rovira C, Davies GJ, Schumann B

September 2024 | Journal article | Journal of the American Chemical Society | Read

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A Facile Method to Quantify Synthetic Peptide Concentrations on Biomaterials

Wojciechowski JP, Benge T, Chen K, Echalier C, Xie R, Stevens MM

September 2024 | Journal article | ACS Applied Materials & Interfaces | Read

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Oligomerization-Driven Avidity Correlates with SARS-CoV-2 Cellular Binding and Inhibition

Asor R, Olerinyova A, Burnap SA, Kushwah MS, Soltermann F, Rudden LSP, Hensen M, Vasiljevic S, Brun J, Hill M, Chang L, Dejnirattisai W, Supasa P, Mongkolsapaya J, Zhou D, Stuart DI, Screaton GR, Degiacomi MT, Zitzmann N, Benesch JLP, Struwe WB, Kukura P

September 2024 | Journal article | PNAS | Read

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Plug and Play Virus-like Particles for the Generation of Anti-toxin Antibodies

Edge RJ, Marriott AE, Stars EL, Patel RN, Wilkinson MC, King LDW, Slagboom J, Tan CH, Ratanabanangkoon K, Draper SJ, Ainsworth S

September 2024 | Journal article | Toxicon: X | Read

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Rapid Identification of Bacterial Isolates Using Microfluidic Adaptive Channels and Multiplexed Fluorescence Microscopy

Chatzimichail S, Turner P, Feehily C, Farrar A, Crook D, Andersson M, Oakley S, Barrett L, El Sayyed H, Kyropoulos J, Nellåker C, Stoesser N, Kapanidis AN

September 2024 | Journal article | Lab on a Chip | Read

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Rational Structure-Guided Design of a Blood Stage Malaria Vaccine Immunogen Presenting a Single Epitope from PfRH5

Harrison TE, Alam N, Farrell B, Quinkert D, Lias AM, King LDW, Barfod LK, Draper SJ, Campeotto I, Higgins MK

September 2024 | Journal article | EMBO Molecular Medicine | Read

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Sensing the Structural and Conformational Properties of Single-Stranded Nucleic Acids Using Electrometry and Molecular Simulations

Walker-Gibbons R, Zhu X, Behjatian A, Bennett TJD, Krishnan M

September 2024 | Journal article | Scientific Reports | Read

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Fillable Magnetic Microrobots for Drug Delivery to Cardiac Tissues In Vitro

Chen MS, Sun R, Wang R, Zuo Y, Zhou K, Kim J, Stevens MM

September 2024 | Journal article | Advanced Healthcare Materials | Read

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Oscillatory-Quality of Sleep Spindles Links Brain State with Sleep Regulation and Function

Blanco-Duque C, Bond SA, Krone LB, Dufour JP, Gillen ECP, Purple RJ, Kahn MC, Bannerman DM, Mann EO, Achermann P, Olbrich E, Vyazovskiy VV

September 2024 | Journal article | Science Advances | Read

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Ablation of Oligodendrogenesis in Adult Mice Alters Brain Microstructure and Activity Independently of Behavioral Deficits

Kaller MS, Lazari A, Feng Y, van der Toorn A, Rühling S, Thomas CW, Shimizu T, Bannerman D, Vyazovskiy V, Richardson WD, Sampaio-Baptista C, Johansen-Berg H

September 2024 | Journal article | Glia | Read

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Author Correction: Covalent Penicillin-protein Conjugates Elicit Anti-drug Antibodies that are Clonally and Functionally Restricted

Deimel LP, Moynié L, Sun G, Lewis V, Turner A, Buchanan CJ, Burnap SA, Kutuzov M, Kobras CM, Demyanenko Y, Mohammed S, Stracy M, Struwe WB, Baldwin AJ, Naismith J, Davis BG, Sattentau QJ

September 2024 | Journal article | Nature Communications | Read

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Molecular Basis of TMED9 Oligomerization and Entrapment of Misfolded Protein Cargo in the Early Secretory Pathway

Xiao L, Pi X, Goss AC, El-Baba T, Ehrmann JF, Grinkevich E, Bazua-Valenti S, Padovano V, Alper SL, Carey D, Udeshi ND, Carr SA, Pablo JL, Robinson CV, Greka A, Wu H

September 2024 | Journal article | Science Advances | Read

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Location and Function of TDP-43 in Platelets, Alterations in Neurodegenerative Diseases and Arising Considerations for Current Plasma Biobank Protocols

Luthi-Carter R, Cappelli S, Le Roux-Bourdieu M, Tentillier N, Quinn JP, Petrozziello T, Gopalakrishnan L, Sethi P, Choudhary H, Bartolini G, Gebara E, Stuani C, Font L, An J, Ortega V, Sage J, Kosa E, Trombetta BA, Simeone R, Seredenina T, Afroz T, Berry JD, Arnold SE, Carlyle BC, Adolfsson O, Sadri-Vakili G, Buratti E, Bowser R, Agbas A

September 2024 | Journal article | Scientific Reports | Read

 

Practical Advice on Measuring and Applying Light for Laboratory Mammals.

Lucas RJ, Peirson SN

August 2024 | Journal article | Journal of Biological Rhythms | Read

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Native MS-guided Lipidomics to Define Endogenous Lipid Microenvironments of Eukaryotic Receptors and Transporters

Wu D, Tang H, Qiu X, Song S, Chen S, Robinson CV

August 2024 | Journal article | Nature Protocols | Read

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Lifting the Concentration Limit of Mass Photometry by PEG Nanopatterning

Kratochvíl J, Asor R, Helmi S, Struwe WB, Kukura P

August 2024 | Journal article | Nano Letters | Read

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Biological Effects of Sodium Phenylbutyrate and Taurursodiol in Alzheimer's Disease

Knowlton N, Williams VJ, Burns JM, Crane M, McManus AJ, Vaishnavi SN, Arvanitakis Z, Neugroschl J, Bell K, Trombetta BA, Carlyle BC, Kivisäkk P, Dodge HH, Tanzi RE, Yeramian PD, Leslie K

August 2024 | Journal article | Alzheimer’s Association | Read

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Covalent Penicillin-protein Conjugates Elicit Anti-drug Antibodies that are Clonally and Functionally Restricted

Deimel LP, Moynié L, Sun G, Lewis V, Turner A, Buchanan CJ, Burnap SA, Kutuzov M, Kobras CM, Demyaneko Y, Mohammed S, Stracy M, Struwe WB, Baldwin AJ, Naismith J, Davis BG, Sattentau QJ

August 2024 | Journal article | Nature Communications | Read

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Infection Inspection: Using the Power of Citizen Science for Image-based Prediction of Antibiotic Resistance in Escherichia Coli Treated with Ciprofloxacin

Farrar A, Feehily C, Turner P, Zagajewski A, Chatzimichail S, Crook D, Andersson M, Oakley S, Barrett L, El Sayyed H, Fowler PW, Nellåker C, Kapanidis AN, Stoesser N

August 2024 | Journal article | Scientific Reports | Read

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ATAXIN-2 Intermediate-length Polyglutamine Expansions Elicit ALS-associated Metabolic and Immune Phenotypes

Vieira de Sá R, Sudria-Lopez E, Cañizares Luna M, Harschnitz O, van den Heuvel DMA, Kling S, Vonk D, Westeneng HJ, Karst H, Bloemenkamp L, Varderidou-Minasian S, Schlegel DK, Mars M, Broekhoven MH, van Kronenburg NCH, Adolfs Y, Vangoor VR, de Jongh R, Ljubikj T, Peeters L, Seeler S, Mocholi E, Basak O, Gordon D, Giuliani F, Verhoeff T, Korsten G, Calafat Pla T, Venø MT, Kjems J, Talbot K, van Es MA, Veldink JH, van den Berg LH, Zelina P, Pasterkamp RJ

August 2024 | Journal article | Nature communications | Read

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Using Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Combined with Machine Learning for Vaccine Authenticity Screening

Clarke R, Bharucha T, Arman BY, Gangadharan B, Gomez Fernandez L, Mosca S, Lin Q, Van Assche K, Stokes R, Dunachie S, Deats M, Merchant HA, Caillet C, Walsby-Tickle J, Probert F, Matousek P, Newton PN, Zitzmann N, McCullagh JSO

August 2024 | Journal article | Npj Vaccines | Read

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Analysis of the Diverse Antigenic Landscape of the Malaria Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

Barrett JR, Pipini D, Wright ND, Cooper AJR, Gorini G, Quinkert D, Lias AM, Davies H, Rigby CA, Aleshnick M, Williams BG, Bradshaw WJ, Paterson NG, Martinson T, Kirtley P, Picard L, Wiggins CD, Donnellan FR, King LDW, Wang LT, Popplewell JF, Silk SE, de Ruiter Swain J, Skinner K, Kotraiah V, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Minassian AM, Lauffenburger DA, Miura K, Long CA, Wilder BK, Koekemoer L, Tan J, Nielsen CM, McHugh K, Draper SJ

July 2024 | Journal article | Cell | Read

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Natural Malaria Infection Elicits Rare but Potent Neutralizing Antibodies to the Blood-stage Antigen RH5

Wang LT, Cooper AJR, Farrell B, Miura K, Diouf A, Müller-Sienerth N, Crosnier C, Purser L, Kirtley PJ, Maciuszek M, Barrett JR, McHugh K, Ogwang R, Tucker C, Li S, Doumbo S, Doumtabe D, Pyo CW, Skinner J, Nielsen CM, Silk SE, Kayentao K, Ongoiba A, Zhao M, Nguyen DC, Lee FE, Minassian AM, Geraghty DE, Traore B, Seder RA, Wilder BK, Crompton PD, Wright GJ, Long CA, Draper SJ, Higgins MK, Tan J

July 2024 | Journal article | Cell | Read

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Ablation of Oligodendrogenesis in Adult Mice Alters Brain Microstructure and Activity Independently of Behavioral Deficits

Kaller MS, Lazari A, Feng Y, van der Toorn A, Rühling S, Thomas CW, Shimizu T, Bannerman D, Vyazovskiy V, Richardson WD, Sampaio-Baptista C, Johansen-Berg H

July 2024 | Journal article | Glia | Read

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Preclinical Development of a Stabilized RH5 Virus-like Particle Vaccine that Induces Improved Antimalarial Antibodies

King LDW, Pulido D, Barrett JR, Davies H, Quinkert D, Lias AM, Silk SE, Pattinson DJ, Diouf A, Williams BG, McHugh K, Rodrigues A, Rigby CA, Strazza V, Suurbaar J, Rees-Spear C, Dabbs RA, Ishizuka AS, Zhou Y, Gupta G, Jin J, Li Y, Carnrot C, Minassian AM, Campeotto I, Fleishman SJ, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Long CA, Miura K, Ashfield R, Skinner K, Howarth MR, Biswas S, Draper SJ

July 2024 | Journal article | Cell Reports Medicine | Read

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A Chemical Reaction Network Drives Complex Population Dynamics in Oscillating Self-Reproducing Vesicles

Zhang Z, Howlett MG, Silvester E, Kukura P, Fletcher SP

July 2024 | Journal article | Journal of the American Chemical Society | Read

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The Mechanism of Mammalian Proton-Coupled Peptide Transporters

Lichtinger SM, Parker JL, Newstead S, Biggin PC

July 2024 | Journal article | ELife | Read

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Recent Insights from Human Induced Pluripotent Stem Cell Models into the Role of Microglia in Amyotrophic Lateral Sclerosis

Nikel LM, Talbot K, Vahsen BF

July 2024 | Journal article | BioEssays | Read

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Lifting the Concentration Limit of Mass Photometry by PEG Nanopatterning

Kratochvíl J, Asor R, Helmi S, Struwe WB, Kukura P

July 2024 | Journal article | Nano Letters | Read

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Molecular Basis for pH Sensing in the KDEL Trafficking Receptor

Wu Z, Smith K, Gerondopoulos A, Sobajima T, Parker JL, Barr FA, Newstead S, Biggin PC

July 2024 | Journal article | Structure | Read

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Functional Diversity Among Cardiolipin Binding Sites on the Mitochondrial ADP/ATP Carrier

Senoo N, Chinthapalli DK, Baile MG, Golla VK, Saha B, Oluwole AO, Ogunbona OB, Saba JA, Munteanu T, Valdez Y, Whited K, Sheridan MS, Chorev D, Alder NN, May ER, Robinson CV, Claypool SM

July 2024 | Journal article | The EMBO Journal | Read

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Astrocytes in Functional Recovery Following Central Nervous System Injuries

Alhadidi QM, Bahader GA, Arvola O, Kitchen P, Shah ZA, Salman MM

July 2024 | Journal article | The Journal of Physiology | Read

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Methods to Estimate Body Temperature and Energy Expenditure Dynamics in Fed and Fasted Laboratory Mice: Effects of Sleep Deprivation and Light Exposure

van der Vinne V, McKillop LE, Wilcox SL, Cantley J, Peirson SN, Swoap SJ, Vyazovskiy VV

June 2024 | Journal article | Journal of Comparative Physiology B | Read

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Phage Defence System CBASS is Regulated by a Prokaryotic E2 Enzyme that Imitates the Ubiquitin Pathway

Yan Y, Xiao J, Huang F, Xian W, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D, Liu X, Wang L, Zhu B

June 2024 | Journal article | Nature Microbiology | Read

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ROS-Dependent S-palmitoylation Activates Cleaved and Intact Gasdermin D

Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H

June 2024 | Journal article | Nature | Read

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A Chemical Reaction Network Drives Complex Population Dynamics in Oscillating Self-Reproducing Vesicles

Zhang Z, Howlett MG, Silvester E, Kukura P, Fletcher SP

June 2024 | Journal article |  Journal of the American Chemical Society | Read

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Blood-stage Malaria Vaccine Candidate RH5.1/Matrix-M in Healthy Tanzanian Adults and Children; an Open-label, Non-randomised, First-in-human, Single-centre, Phase 1b Trial

Silk SE, Kalinga WF, Salkeld J, Mtaka IM, Ahmed S, Milando F, Diouf A, Bundi CK, Balige N, Hassan O, Mkindi CG, Rwezaula S, Athumani T, Mswata S, Lilolime NS, Simon B, Msami H, Mohamed M, David DM, Mohammed L, Nyaulingo G, Mwalimu B, Juma O, Mwamlima TG, Sasamalo IA, Mkumbange RP, Kamage JJ, Barrett JR, King LDW, Hou MM, Pulido D, Carnrot C, Lawrie AM, Cowan RE, Nugent FL, Roberts R, Cho JS, Long CA, Nielsen CM, Miura K, Draper SJ, Olotu AI, Minassian AM

June 2024 | Journal article |  The Lancet Infectious Diseases | Read

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Development of an Improved Blood-stage Malaria Vaccine Targeting the Essential RH5-CyRPA-RIPR Invasion Complex

Williams BG, King LDW, Pulido D, Quinkert D, Lias AM, Silk SE, Ragotte RJ, Davies H, Barrett JR, McHugh K, Rigby CA, Alanine DGW, Barfod L, Shea MW, Cowley LA, Dabbs RA, Pattinson DJ, Douglas AD, Lyth OR, Illingworth JJ, Jin J, Carnrot C, Kotraiah V, Christen JM, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Skinner K, Miura K, Long CA, Higgins MK, Draper SJ

June 2024 | Journal article |  Nature Communications | Read

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Functional Diversity Among Cardiolipin Binding Sites on the Mitochondrial ADP/ATP Carrier

Senoo N, Chinthapalli DK, Baile MG, Golla VK, Saha B, Oluwole AO, Ogunbona OB, Saba JA, Munteanu T, Valdez Y, Whited K, Sheridan MS, Chorev D, Alder NN, May ER, Robinson CV, Claypool SM

June 2024 | Journal article |  The EMBO Journal | Read

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Cellular and Axonal Transport Phenotypes due to the C9ORF72 HRE in iPSC Motor and Sensory Neurons

Scaber J, Thomas-Wright I, Clark AJ, Xu Y, Vahsen BF, Carcolé M, Dafinca R, Farrimond L, Isaacs AM, Bennett DL, Talbot K

June 2024 | Journal article |  Stem Cell Reports | Read

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Body Weight Modulates the Impact of Oxytocin on Chronic Cold-immobilization Stress Response

Önal D, Korkmaz H, Önal G, Pehlivanoğlu B

June 2024 | Journal article |  Peptites | Read

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Structural Basis for IL-33 Recognition and its Antagonism by the Helminth Effector Protein HpARI2

Jamwal A, Colomb F, McSorley HJ, Higgins MK

June 2024 | Journal article |  Nature Communications | Read

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Plasma VEGFA and PGF Impact Longitudinal Tau and Cognition in Preclinical Alzheimer's Disease

Yang HS, Yau WW, Carlyle BC, Trombetta BA, Zhang C, Shirzadi Z, Schultz AP, Pruzin JJ, Fitzpatrick CD, Kirn DR, Rabin JS, Buckley RF, Hohman TJ, Rentz DM, Tanzi RE, Johnson KA, Sperling RA, Arnold SE, Chhatwal JP

June 2024 | Journal article |  Brain | Read

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Paired Plasma Lipidomics and Proteomics Analysis in the Conversion from Mild Cognitive Impairment to Alzheimer's Disease

Gómez-Pascual A, Naccache T, Xu J, Hooshmand K, Wretlind A, Gabrielli M, Lombardo MT, Shi L, Buckley NJ, Tijms BM, Vos SJB, Ten Kate M, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, Popp J, Martinez-Lage P, Streffer J, Barkhof F, Zetterberg H, Visser PJ, Lovestone S, Bertram L, Nevado-Holgado AJ, Gualerzi A, Picciolini S, Proitsi P, Verderio C, Botía JA, Legido-Quigley C

May 2024 | Journal article |  Computers in Biology and Medicine | Read

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Ultrasonic Vocalisation Rate Tracks the Diurnal Pattern of Activity in Winter Phenotype Djungarian Hamsters (Phodopus sungorus)

Harding CD, Walker KMM, Hackett TD, Herwig A, Peirson SN, Vyazovskiy VV

May 2024 | Journal article |  Journal of Comparative Physiology B | Read

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Extracellular Modulation of TREK-2 Activity with Nanobodies Provides Insight into the Mechanisms of K2P Channel Regulation

Rödström KEJ, Cloake A, Sörmann J, Baronina A, Smith KHM, Pike ACW, Ang J, Proks P, Schewe M, Holland-Kaye I, Bushell SR, Elliott J, Pardon E, Baukrowitz T, Owens RJ, Newstead S, Steyaert J, Carpenter EP, Tucker SJ

May 2024 | Journal article | Nature Communications | Read

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Evaluation of the Precision of the Plasmodium Knowlesi Growth Inhibition Assay for Plasmodium Vivax Duffy-binding Protein-based Malaria Vaccine Development

Mertens JE, Rigby CA, Bardelli M, Quinkert D, Hou MM, Diouf A, Silk SE, Chitnis CE, Minassian AM, Moon RW, Long CA, Draper SJ, Miura K

May 2024 | Journal article | Vaccine | Read

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An ALS-associated Mutation Dysregulates Microglia-derived Extracellular MicroRNAs in a Sex-specific Manner

Christoforidou E, Moody L, Joilin G, Simoes FA, Gordon D, Talbot K, Hafezparast M

May 2024 | Journal article | Disease Models and Mechanisms | Read

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BERNN: Enhancing Classification of Liquid Chromatography Mass Spectrometry Data with Batch Effect Removal Neural Networks

Pelletier SJ, Leclercq M, Roux-Dalvai F, de Geus MB, Leslie S, Wang W, Lam TT, Nairn AC, Arnold SE, Carlyle BC, Precioso F, Droit A

May 2024 | Journal article | Nature Communications | Read

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Recent Insights from Human Induced Pluripotent Stem Cell Models into the Role of Microglia in Amyotrophic Lateral Sclerosis

Nikel LM, Talbot K, Vahsen BF

May 2024 | Journal article | BioEssays | Read

---

Fillable Magnetic Microrobots for Drug Delivery to Cardiac Tissues In Vitro

Chen MS, Sun R, Wang R, Zuo Y, Zhou K, Kim J, Stevens MM

May 2024 | Journal article | Advanced Healthcare Materials | Read

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4D Multimaterial Printing of Soft Actuators with Spatial and Temporal Control

Zhou K, Sun R, Wojciechowski JP, Wang R, Yeow J, Zuo Y, Song X, Wang C, Shao Y, Stevens MM

May 2024 | Journal article | Advanced Materials | Read

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The Complete Assembly of Human LAT1-4F2hc Complex Provides Insights into its Regulation, Function and Localisation

Wu D, Yan R, Song S, Swansiger AK, Li Y, Prell JS, Zhou Q, Robinson CV

May 2024 | Journal article | Nature Communications | Read

 

Data-independent Acquisition Proteomics of Cerebrospinal Fluid Implicates Endoplasmic Reticulum and Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis.

Dellar ER, Vendrell I, Talbot K, Kessler BM, Fischer R, Turner MR, Thompson AG

December 2023 | Journal article | Journal of Neurochemistry | Read

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Mass Spectrometry in Cerebrospinal Fluid Uncovers Association of Glycolysis Biomarkers with Alzheimer's Disease in a Large Clinical Sample.

de Geus MB, Leslie SN, Lam T, Wang W, Roux-Dalvai F, Droit A, Kivisakk P, Nairn AC, Arnold SE, Carlyle BC

December 2023 | Journal article | Scientific Reports | Read

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Mutant GGGGCC RNA Prevents YY1 from Binding to Fuzzy Promoter which Stimulates Wnt/β-catenin Pathway in C9ALS/FTD.

Chen ZS, Ou M, Taylor S, Dafinca R, Peng SI, Talbot K, Chan HYE

December 2023 | Journal article | Nature Communications | Read

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Mechanisms of aquaporin-4 Vesicular Trafficking in Mammalian Cells.

Markou A, Kitchen P, Aldabbagh A, Repici M, Salman MM, Bill RM, Balklava Z

December 2023 | Journal article | Journal of Neurochemistry | Read

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Correction: Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-deficient Neurons.

Hasan S, Fernandopulle MS, Humble SW, Frankenfield AM, Li H, Prestil R, Johnson KR, Ryan BJ, Wade-Martins R, Ward ME, Hao L

December 2023 | Journal article | Molecular Neurodegeneration | Read

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The PfRCR Complex Bridges Malaria Parasite and Erythrocyte During Invasion.

Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK

December 2023 | Journal article | Nature | Read

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Multilayer DNA Origami with Terminal Interfaces That Are Flat and Wide-Area.

Kilwing L, Lill P, Nathwani B, Guerra R, Benson E, Liedl T, Shih WM

December 2023 | Journal article | ACS Nano | Read

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Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease.

Yan S, Jiang C, Janzen A, Barber TR, Seger A, Sommerauer M, Davis JJ, Marek K, Hu MT, Oertel WH, Tofaris GK

December 2023 | Journal article | JAMA Neurology | Read

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Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-deficient Neurons.

Hasan S, Fernandopulle MS, Humble SW, Frankenfield AM, Li H, Prestil R, Johnson KR, Ryan BJ, Wade-Martins R, Ward ME, Hao L

November 2023 | Journal article | Molecular Neurodegeneration | Read

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Aberrant Topologies of Bacterial Membrane Proteins Revealed by High Sensitivity Fluorescence Labelling.

Hickman SJ, Miller HL, Bukys A, Kapanidis AN, Berks BC

November 2023 | Journal article | Journal of Molecular Biology | Read

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Molecular Basis for Selective Uptake and Elimination of Organic Anions in the Kidney by OAT1.

Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S

November 2023 | Journal article | Nature Structural & Molecular Biology | Read

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Penguins Snatch Seconds-long Microsleeps.

Harding CD, Vyazovskiy VV

November 2023 | Journal article | Science | Read

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Deep Learning and Single-cell Phenotyping for Rapid Antimicrobial Susceptibility Detection in Escherichia coli.

Zagajewski A, Turner P, Feehily C, El Sayyed H, Andersson M, Barrett L, Oakley S, Stracy M, Crook D, Nellåker C, Stoesser N, Kapanidis AN

November 2023 | Journal article | Communications Biology | Read

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Methodological Considerations in Neuronal Extracellular Vesicle Isolation for α-synuclein Biomarkers.

Yan S, Jiang C, Davis JJ, Tofaris GK

November 2023 | Journal article | Brain | Read

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Brain Stimulation Techniques as Novel Treatment Options for Insomnia: A Systematic Review.

Krone LB, Fehér KD, Rivero T, Omlin X

November 2023 | Journal article | Journal of Sleep Research | Read

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Trypanosomes and Complement: More Than One Way to Die?

Cook AD, Carrington M, Higgins MK

November 2023 | Journal article | Trends in Parasitology | Read

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Biocatalytic Reductive Amination as a Route to Isotopically Labelled Amino Acids Suitable for Analysis of Large Proteins by NMR.

Rowbotham JS, Nicholson JH, Ramirez MA, Urata K, Todd PMT, Karunanithy G, Lauterbach L, Reeve HA, Baldwin AJ, Vincent KA

November 2023 | Journal article | Chemical Science | Read

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Innovative Method for Rapid Detection of Falsified COVID-19 Vaccines through Unopened Vials Using Handheld Spatially Offset Raman Spectroscopy (SORS).

Mosca S, Lin Q, Stokes R, Bharucha T, Gangadharan B, Clarke R, Fernandez LG, Deats M, Walsby-Tickle J, Arman BY, Chunekar SR, Patil KD, Gairola S, Van Assche K, Dunachie S, Merchant HA, Kuwana R, Maes A, McCullagh J, Caillet C, Zitzmann N, Newton PN, Matousek P

October 2023 | Journal article | Vaccine | Read

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Erythrocyte Invasion-neutralising Antibodies Prevent Plasmodium Falciparum RH5 from Binding to Basigin-containing Membrane Protein Complexes.

Jamwal A, Constantin CF, Hirschi S, Henrich S, Bildl W, Fakler B, Draper SJ, Schulte U, Higgins MK

October 2023 | Journal article | Elife | Read

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A Quinolin-8-ol Sub-millimolar Inhibitor of UGGT, the ER Glycoprotein Folding Quality Control Checkpoint.

Guay KP, Ibba R, Kiappes JL, Vasiljević S, Bonì F, De Benedictis M, Zeni I, Le Cornu JD, Hensen M, Chandran AV, Kantsadi AL, Caputo AT, Blanco Capurro JI, Bayo Y, Hill JC, Hudson K, Lia A, Brun J, Withers SG, Martí M, Biasini E, Santino A, De Rosa M, Milani M, Modenutti CP, Hebert DN, Zitzmann N, Roversi P

October 2023 | Journal article | iScience | Read

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Structural Basis for Triacylglyceride Extraction from Mycobacterial Inner Membrane by MFS Transporter Rv1410.

Remm S, De Vecchis D, Schöppe J, Hutter CAJ, Gonda I, Hohl M, Newstead S, Schäfer LV, Seeger MA

October 2023 | Journal article | Nature Communications | Read

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Single Particle Chemical Characterisation of Nanoformulations for Cargo Delivery.

Saunders C, de Villiers CA, Stevens MM

October 2023 | Journal article | The AAPS Journal | Read

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Patient-derived iPSC Models of Friedreich Ataxia: A New Frontier for Understanding Disease Mechanisms and Therapeutic Application.

Maheshwari S, Vilema-Enríquez G, Wade-Martins R

September 2023 | Journal article | Translational Neurodegeneration | Read

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A New Twist on PIFE: Photoisomerisation-related Fluorescence Enhancement.

Ploetz E, Ambrose B, Barth A, Börner R, Erichson F, Kapanidis AN, Kim HD, Levitus M, Lohman TM, Mazumder A, Rueda D, Steffen FD, Cordes T, Magennis S, Lerner E

September 2023 | Journal article | Methods and Applications in Fluorescence | Read

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Trypanosomes and Complement: More than One Way to Die?

Cook AD, Carrington M, Higgins MK

September 2023 | Journal article | Trends in Parasitology | Read

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Astrocytes in Functional Recovery Following Central Nervous System Injuries.

Alhadidi QM, Bahader GA, Arvola O, Kitchen P, Shah ZA, Salman MM

September 2023 | Journal article | The Journal of Physiology | Read

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PRMT Inhibitor Promotes SMN2 Exon 7 Inclusion and Synergizes with Nusinersen to Rescue SMA Mice.

Kordala AJ, Stoodley J, Ahlskog N, Hanifi M, Garcia Guerra A, Bhomra A, Lim WF, Murray LM, Talbot K, Hammond SM, Wood MJ, Rinaldi C

September 2023 | Journal article | EMBO Molecular Medicine | Read

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C9orf72-ALS Human iPSC Microglia are Pro-inflammatory and Toxic to Co-cultured Motor Neurons via MMP9.

Vahsen BF, Nalluru S, Morgan GR, Farrimond L, Carroll E, Xu Y, Cramb KML, Amein B, Scaber J, Katsikoudi A, Candalija A, Carcolé M, Dafinca R, Isaacs AM, Wade-Martins R, Gray E, Turner MR, Cowley SA, Talbot K

September 2023 | Journal article | Nature Communications | Read

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Mitochondrial Dysfunction and Mitophagy Defects in LRRK2-R1441C Parkinson's Disease Models.

Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Malpartida AB, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R

September 2023 | Journal article | Human Molecular Genetics | Read

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Infrared Multiphoton Dissociation Enables Top-Down Characterization of Membrane Protein Complexes and G Protein-Coupled Receptors.

Lutomski CA, El-Baba TJ, Hinkle JD, Liko I, Bennett JL, Kalmankar NV, Dolan A, Kirschbaum C, Greis K, Urner LH, Kapoor P, Yen HY, Pagel K, Mullen C, Syka JEP, Robinson CV

September 2023 | Journal article | Angewandte Chemie | Read

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Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson's Disease Patients Carrying the Heterozygous Mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1.

Chemla A, Arena G, Onal G, Walter J, Berenguer-Escuder C, Grossmann D, Grünewald A, Schwamborn JC, Krüger R

September 2023 | Journal article | Stem Cell Research | Read

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The Dual Action of Human Antibodies Specific to Plasmodium Falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites.

Weiss GE, Ragotte RJ, Quinkert D, Lias AM, Dans MG, Boulet C, Looker O, Ventura OD, Williams BG, Crabb BS, Draper SJ, Gilson PR

September 2023 | Journal article | PLoS Pathogens | Read

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Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels.

Cole BA, Becker EBE

September 2023 | Journal article | Cells | Read

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Structural Characterization of Human Urea Transporters UT-A and UT-B and Their Inhibition.

Chi G, Dietz L, Tang H, Snee M, Scacioc A, Wang D, Mckinley G, Mukhopadhyay SMM, Pike ACW, Chalk R, Burgess-Brown NA, Timmermans JP, van Putte W, Robinson CV, Dürr KL

September 2023 | Journal article | Science Advances | Read

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Continuous Home Cage Monitoring of Activity and Sleep in Mice During Repeated Paroxetine Treatment and Discontinuation.

Collins HM, Pinacho R, Tam SKE, Sharp T, Bannerman DM, Peirson SN

August 2023 | Journal article | Psychopharmacology | Read

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Correction to "Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease".

Quinn JP, Ethier EC, Novielli A, Malone A, Ramirez CE, Salloum L, Trombetta BA, Kivisäkk P, Bremang M, Selzer S, Fournier M, Das S, Xing Y, Arnold SE, Carlyle BC

August 2023 | Journal article | Journal of the American Society for Mass Spectrometry | Read

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Transcending Markov: Non-Markovian Rate Processes of Thermosensitive TRP Ion Channels.

Ben-Abu Y, Tucker SJ, Contera S

August 2023 | Journal article | Royal Society Open Sci | Read

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Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.

Burnap SA, Ortega-Prieto AM, Jimenez-Guardeño JM, Ali H, Takov K, Fish M, Shankar-Hari M, Giacca M, Malim MH, Mayr M

August 2023 | Journal article | Molecular & Cellular Proteomics | Read

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Advantages of Routine Next-generation Sequencing Over Standard Genetic Testing in the Amyotrophic Lateral Sclerosis Clinic.

Scaber J, Thompson AG, Farrimond L, Feneberg E, Proudfoot M, Ossher L, Turner MR, Talbot K

August 2023 | Journal article | European Journal of Neuralogy | Read

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RNA Polymerase Redistribution Supports Growth in E. coli Strains with a Minimal Number of rRNA Operons.

Fan J, El Sayyed H, Pambos OJ, Stracy M, Kyropoulos J, Kapanidis AN

August 2023 | Journal article | Nucleic Acids Research | Read

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A Quantitative Description for Optical Mass Measurement of Single Biomolecules.

Becker J, Peters JS, Crooks I, Helmi S, Synakewicz M, Schuler B, Kukura P

August 2023 | Journal article | ACS Photonics | Read

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Superior Antibody Immunogenicity of a Viral-vectored RH5 Blood-stage Malaria Vaccine in Tanzanian Infants as Compared to Adults.

Silk SE, Kalinga WF, Mtaka IM, Lilolime NS, Mpina M, Milando F, Ahmed S, Diouf A, Mkwepu F, Simon B, Athumani T, Rashid M, Mohammed L, Lweno O, Ali AM, Nyaulingo G, Mwalimu B, Mswata S, Mwamlima TG, Barrett JR, Wang LT, Themistocleous Y, King LDW, Hodgson SH, Payne RO, Nielsen CM, Lawrie AM, Nugent FL, Cho JS, Long CA, Miura K, Draper SJ, Minassian AM, Olotu AI

August 2023 | Journal article | Clinical Advances | Read

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The Solute Carrier SPNS2 Recruits PI(4,5)P₂ to Synergistically Regulate Transport of Sphingosine-1-Phosphate.

Tang H, Li H, Prakaash D, Pedebos C, Qiu X, Sauer DB, Khalid S, Duerr K, Robinson CV

August 2023 | Journal article | Molecular Science | Read

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Structural Basis of Telomeric Nucleosome Recognition by Shelterin Factor TRF1.

Hu H, van Roon AM, Ghanim GE, Ahsan B, Oluwole AO, Peak-Chew SY, Robinson CV, Nguyen THD

August 2023 | Journal article | Science Advances | Read

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ProSight Native: Defining Protein Complex Composition from Native Top-Down Mass Spectrometry Data.

Durbin KR, Robey MT, Voong LN, Fellers RT, Lutomski CA, El-Baba TJ, Robinson CV, Kelleher NL

August 2023 | Journal article | Journal of Proteome Research | Read

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A Review of Broadly Protective Monoclonal Antibodies to Treat Ebola Virus Disease.

Rijal P, Donnellan FR

August 2023 | Journal article | Current Opinion in Virology | Read

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Impaired Dopamine Release in Parkinson's Disease.

Cramb KML, Beccano-Kelly D, Cragg SJ, Wade-Martins R

August 2023 | Journal article | Brain | Read

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Visualization of Direct and Diffusion-assisted RAD51 Nucleation by Full-length Human BRCA2 Protein.

Belan O, Greenhough L, Kuhlen L, Anand R, Kaczmarczyk A, Gruszka DT, Yardimci H, Zhang X, Rueda DS, West SC, Boulton SJ

July 2023 | Journal article | Molecular Cell | Read

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The Solute Carrier SPNS2 Recruits PI(4,5)P₂ to Synergistically Regulate Transport of Sphingosine-1-Phosphate.

Tang H, Li H, Prakaash D, Pedebos C, Qiu X, Sauer DB, Khalid S, Duerr K, Robinson CV

July 2023 | Journal article | Molecular Cell | Read

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Molecular Basis for Selective Uptake and Elimination of Organic Anions in the Kidney by OAT1

Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S

July 2023 | Journal article | Nature Structural & Molecular Biology | Read

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Correction: Limitations of Non-polarizable Force Fields in Describing Anion Binding Poses in Non-polar Synthetic Hosts

Seiferth D, Tucker SJ, Biggin PC

July 2023 | Journal article | Physical Chemistry Chemical Physics | Read

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The Beauty and Complexity of the Small Heat Shock Proteins: A Report on the Proceedings of the Fourth Workshop on Small Heat Shock Proteins.

Ecroyd H, Bartelt-Kirbach B, Ben-Zvi A, Bonavita R, Bushman Y, Casarotto E, Cecconi C, Lau WCY, Hibshman JD, Joosten J, Kimonis V, Klevit R, Liberek K, McMenimen KA, Miwa T, Mogk A, Montepietra D, Peters C, Rocchetti MT, Saman D, Sisto A, Secco V, Strauch A, Taguchi H, Tanguay M, Tedesco B, Toth ME, Wang Z, Benesch JLP, Carra S

July 2023 | Journal article | Cell Stress and Chaperones | Read

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Vaccination with Plasmodium vivax Duffy-binding Protein Inhibits Parasite Growth During Controlled Human Malaria Infection.

Hou MM, Barrett JR, Themistocleous Y, Rawlinson TA, Diouf A, Martinez FJ, Nielsen CM, Lias AM, King LDW, Edwards NJ, Greenwood NM, Kingham L, Poulton ID, Khozoee B, Goh C, Hodgson SH, Mac Lochlainn DJ, Salkeld J, Guillotte-Blisnick M, Huon C, Mohring F, Reimer JM, Chauhan VS, Mukherjee P, Biswas S, Taylor IJ, Lawrie AM, Cho JS, Nugent FL, Long CA, Moon RW, Miura K, Silk SE, Chitnis CE, Minassian AM, Draper SJ

July 2023 | Journal article | Science Translational Medicine | Read

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ProSight Native: Defining Protein Complex Composition from Native Top-Down Mass Spectrometry Data.

Durbin KR, Robey MT, Voong LN, Fellers RT, Lutomski CA, El-Baba TJ, Robinson CV, Kelleher NL

July 2023 | Journal article | Journal of Proteome Research | Read

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​​​​​Dimerization of European Robin Cryptochrome 4a.

Hanić M, Antill LM, Gehrckens AS, Schmidt J, Görtemaker K, Bartölke R, El-Baba TJ, Xu J, Koch KW, Mouritsen H, Benesch JLP, Hore PJ, Solov'yov IA

July 2023 | Journal article | The Journal of Physical Chemistry | Read

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Calcium Dysregulation Combined with Mitochondrial Failure and Electrophysiological Maturity Converge in Parkinson's iPSC-dopamine Neurons.

Beccano-Kelly DA, Cherubini M, Mousba Y, Cramb KML, Giussani S, Caiazza MC, Rai P, Vingill S, Bengoa-Vergniory N, Ng B, Corda G, Banerjee A, Vowles J, Cowley S, Wade-Martins R

July 2023 | Journal article | iScience | Read

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Recent Advances in Membrane Mimetics for Membrane Protein Research.

Young JW

Jun 2023 | Journal article | Biochemical Society Transactions | Read

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Bleaching-resistant, Near-continuous Single-molecule Fluorescence and FRET Based on Fluorogenic and Transient DNA Binding.

Kümmerlin M, Mazumder A, Kapanidis AN

Jun 2023 | Journal article | ChemPhysChem | Read

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Monitoring α-synuclein Ubiquitination Dynamics Reveals Key Endosomal Effectors Mediating its Trafficking and Degradation.

Zenko D, Marsh J, Castle AR, Lewin R, Fischer R, Tofaris GK

Jun 2023 | Journal article | Science Advances | Read

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Mitochondrial Dysfunction and Mitophagy Defects in LRRK2-R1441C Parkinson's Disease Models.

Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Belen Malpartida A, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R

Jun 2023 | Journal article | Human Molecular Genetics | Read

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Effect of Temperature and Nucleotide on the Binding of BiP Chaperone to a Protein Substrate.

Rivera M, Burgos-Bravo F, Engelberger F, Asor R, Lagos-Espinoza MIA, Figueroa M, Kukura P, Ramírez-Sarmiento CA, Baez M, Smith SB, Wilson CAM

Jun 2023 | Journal article | Protein Science | Read

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High-throughput Super-resolution Analysis of Influenza Virus Pleomorphism Reveals Insights into Viral Spatial Organization.

McMahon A, Andrews R, Groves D, Ghani SV, Cordes T, Kapanidis AN, Robb NC

Jun 2023 | Journal article | PLoS Pathogens | Read

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Cross-linking Mass Spectrometry Uncovers Interactions Between High-density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.

Burnap SA, Ortega-Prieto AM, Jimenez-Guardeño JM, Ali H, Takov K, Fish M, Shankar-Hari M, Giacca M, Malim MH, Mayr M

Jun 2023 | Journal article | Molecular & Cellular Proteomics | Read

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Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson's Disease Patients Carrying the Heterozygous Mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1.

Chemla A, Arena G, Onal G, Walter J, Berenguer-Escuder C, Grossmann D, Grünewald A, Schwamborn JC, Krüger R

Jun 2023 | Journal article | Stem Cell Research | Read

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RNA polymerase Redistribution Supports Growth in E. coli Strains with a Minimal Number of rRNA Operons.

Fan J, El Sayyed H, Pambos OJ, Stracy M, Kyropoulos J, Kapanidis AN

Jun 2023 | Journal article | Nucleic Acids Research | Read

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Limitations of Non-polarizable Force Fields in Describing Anion Binding Poses in Non-polar Synthetic Hosts.

Seiferth D, Tucker SJ, Biggin PC

Jun 2023 | Journal article | Physical Chemistry Chemical Physics | Read

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Rationalizing the Optimization of Detergents for Membrane Protein Purification.

Urner LH, Junge F, Fiorentino F, El-Baba TJ, Shutin D, Nölte G, Haag R, Robinson CV

May 2023 | Journal article | Chemistry Europe | Read

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Methodological Considerations in Neuronal Extracellular Vesicle Isolation for α-synuclein Biomarkers.

Yan S, Jiang C, Davis JJ, Tofaris GK

May 2023 | Journal article | Brain | Read

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Brain Stimulation Techniques as Novel Treatment Options for Insomnia: A Systematic Review.

Krone LB, Fehér KD, Rivero T, Omlin X

May 2023 | Journal article | Journal of Sleep Research | Read

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Single-molecule FRET for Virology: 20 Years of Insight into Protein Structure and Dynamics.

Groves D, Hepp C, Kapanidis AN, Robb NC

May 2023 | Journal article | Quarterly Reviews of Biophysics | Read

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Deep Proteomics Network and Machine Learning Analysis of Human Cerebrospinal Fluid in Japanese Encephalitis Virus Infection.

Bharucha T, Gangadharan B, Kumar A, Myall AC, Ayhan N, Pastorino B, Chanthongthip A, Vongsouvath M, Mayxay M, Sengvilaipaseuth O, Phonemixay O, Rattanavong S, O'Brien DP, Vendrell I, Fischer R, Kessler B, Turtle L, de Lamballerie X, Dubot-Pérès A, Newton PN, Zitzmann N, SEAe Consortium

May 2023 | Journal article | Journal of Proteome Research | Read

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α-Synuclein Fibril and Synaptic Vesicle Interactions Lead to Vesicle Destruction and Increased Lipid-Associated Fibril Uptake into iPSC-derived Neurons.

Stephens AD, Villegas AF, Chung CW, Vanderpoorten O, Pinotsi D, Mela I, Ward E, McCoy TM, Cubitt R, Routh AF, Kaminski CF, Kaminski Schierle GS

May 2023 | Journal article | Communications Biology | Read

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A Modular RNA Delivery System Comprising Spherical Nucleic Acids Built on Endosome-escaping Polymeric Nanoparticles.

Garcia-Guerra A, Ellerington R, Gaitzsch J, Bath J, Kye M, Varela MA, Battaglia G, Wood MJA, Manzano R, Rinaldi C, Turberfield AJ.

May 2023 | Journal article | Nanoscale Advances | Read

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Alternating Magnetic Field-Promoted Nanoparticle Mixing: The On-Chip Immunocapture of Serum Neuronal Exosomes for Parkinson's Disease Diagnostics.

Sharafeldin M, Yan S, Jiang C, Tofaris GK, Davis JJ

May 2023 | Journal article | Analytical Chemistry | Read

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Advantages of Routine Next Generation Sequencing Over Standard Genetic Testing in the ALS Clinic.

Scaber J, Thompson AG, Farrimond L, Feneberg E, Proudfoot M, Ossher L, Turner MR, Talbot K

May 2023 | Journal article | Europen Journal of Neurology | Read

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G Protein-Coupled Receptor Pharmacology-Insights from Mass Spectrometry

Yen HY, Jazayeri A, Robinson CV

May 2023 | Journal article | Pharmacological Reviews | Read

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Temporal Transcriptional Control of Neural Induction in Human Induced Pluripotent Stem Cells

Gupta S, Polit LD, Fitzgerald M, Rowland HA, Murali D, Buckley NJ, Subramaniam S

May 2023 | Journal article | Frontiers in Molecular Neuroscience | Read

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Reconfigurable Self-Assembled DNA Devices

Benson E, Bath J

April 2023 | Journal article | Science Robotics | Read

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Bleaching-resistant, Near-continuous Single-molecule Fluorescence and FRET Based on Fluorogenic and Transient DNA Binding

Kümmerlin M, Mazumder A, Kapanidis AN

April 2023 | Journal article | Chemphyschem | Read

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Reliability and Accuracy of Single-molecule FRET Studies for Characterization of Structural Dynamics and Distances in Proteins

Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T

April 2023 | Journal article | Nature Methods | Read

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Shapeshifting Bullvalene-linked Vancomycin Dimers as Effective Antibiotics Against Multidrug-resistant Gram-positive Bacteria

Ottonello A, Wyllie JA, Yahiaoui O, Sun S, Koelln RA, Homer JA, Johnson RM, Murray E, Williams P, Bolla JR, Robinson CV, Fallon T, Soares da Costa TP, Moses JE

April 2023 | Journal article | PNAS | Read

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Fortuitously Compatible Protein Surfaces Primed Allosteric Control in Cyanobacterial Photoprotection

Steube N, Moldenhauer M, Weiland P, Saman D, Kilb A, Rojas AAR, Garg SG, Schindler D, Graumann PL, Benesch JLP, Bange G, Friedrich T, Hochberg GKA

April 2023 | Journal article | Nature Ecology & Evolution | Read

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Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease

Quinn JP, Ethier EC, Novielli A, Malone A, Ramirez CE, Salloum L, Trombetta BA, Kivisäkk P, Bremang M, Selzer S, Fournier M, Das S, Xing Y, Arnold SE, Carlyle BC

March 2023 | Journal article | Journal of the American Society for Mass Spectrometry | Read

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An in-solution Snapshot of SARS-COV-2 Main Protease Maturation Process and Inhibition

Noske GD, Song Y, Fernandes RS, Chalk R, Elmassoudi H, Koekemoer L, Owen CD, El-Baba TJ, Robinson CV, COVID Moonshot Consortium, Oliva G, Godoy AS 

March 2023 | Journal article | Nature Communications | Read

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Influence of Electronic Polarization on the Binding of Anions to a Chloride-pumping Rhodopsin

Phan LX, Chamorro VC, Martinez-Seara H, Crain J, Sansom MSP, Tucker SJ

March 2023 | Journal article | Biophysical Journal | Read

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A Special Issue of Essays in Biochemistry on Structural Mass Spectrometry

Britt HM, Beveridge R , Calabrese AN

March 2023 | Journal article | Essays Biochem | Read

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Uncovering the Role of N-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry

El-Baba TJ, Lutomski CA, Burnap SA, Bolla JR, Baker LA, Baldwin AJ, Struwe WB, Robinson CV

March 2023 | Journal article | JACS | Read

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Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays

Tyrrell BE, Kumar A, Gangadharan B, Alonzi D, Brun J, Hill M, Bharucha T, Bosworth A, Graham V, Dowall S, Miller JL, Zitzmann N

March 2023 | Journal article | Pathogens | Read

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A Quantitative Description for Optical Mass Measurement of Single Biomolecules

Becker J, Peters JS, Crooks I, Helmi S, Synakewicz M, Schuler B, Kukura P

March 2023 | Journal article | bioRxiv | Read

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Post-translational Proteomics Platform Identifies Neurite Outgrowth Impairments in Parkinson's Disease GBA-N370S Dopamine Neurons 

Bogetofte H, Ryan BJ, Jensen P, Schmidt SI, Vergoossen DLE, Barnkob MB, Kiani LN, Chughtai U, Heon-Roberts R, Caiazza MC, McGuinness W, Márquez-Gómez R, Vowles J, Bunn FS, Brandes J, Kilfeather P, Connor JP, Fernandes HJR, Caffrey TM, Meyer M, Cowley SA, Larsen MR, Wade-Martins R

March 2023 | Journal article | Cell Reports | Read

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In Conversation with Carol Robinson 

Dhillon P, Robinson C.

March 2023 | Journal article | Febs | Read

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Effects of Clozapine-N-oxide and Compound 21 on Sleep in Laboratory Mice 

Traut J, Mengual JP, Meijer EJ, McKillop LE, Alfonsa H, Hoerder-Suabedissen A, Song SH, Fehér KD, Riemann D, Molnar Z, Akerman CJ, Vyazovskiy VV, Krone LB

March 2023 | Journal article | eLife | Read

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Rationalizing the Optimization of Detergents for Membrane Protein Purification

Urner LH, Junge F, Fiorentino F, El-Baba TJ, Shutin D, Nölte G, Haag R, Robinson CV

March 2023 | Journal article | Chemistry | Read

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Impaired Dopamine Release in Parkinson’s Disease

Cramb KML,  Beccano-Kelly D,  Cragg SJ, Wade-Martins R

March 2023 | Journal article | Brain | Read

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Mass Spectrometry of Intact Membrane Proteins: Shifting Towards a More Native-like Context

Oluwole A, Shutin D, Bolla JR

February 2023 | Journal article | Essays in Biochemistry | Read

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Posttranslational, Site-directed Photochemical Fluorine Editing of Protein Sidechains to Probe Residue Oxidation State via ¹⁹F-nuclear Magnetic Resonance 

Isenegger PG, Josephson B, Gaunt B, Davy MJ, Gouverneur V, Baldwin AJ, Davis BG

February 2023 | Journal article | Nature Protocols | Read

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Detection of Neuronal OFF Periods as Low Amplitude Neural Activity Segments 

Harding CD, Guillaumin MCC, Krone LB, Kahn MC, Blanco-Duque C, Mikutta C, Vyazovskiy VV

February 2023 | Journal article | BMC Neuroscience | Read

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HS 3D-SeboSkin Model Enables the Preclinical Exploration of Therapeutic Candidates for Hidradenitis Suppurativa/Acne Inversa 

Cramb KML,  Beccano-Kelly D,  Cragg SJ, Wade-Martins R

February 2023 | Journal article | Pharmaceutics | Read

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Functional Integrity of Visual Coding Following Advanced Photoreceptor Degeneration

Rodgers J, Hughes S, Lindner M, Allen AE, Ebrahimi AS, Storchi R, Peirson SN, Lucas RJ, Hankins MW

January 2023 | Journal article | Current Biology | Read

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Efficiently Computing the Uhlmann Fidelity for Density Matrices

Baldwin AJ and Jones JA

January 2023 | Journal article | Physical Review A | Read

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Unconventional Secretion of alpha-synuclein Mediated by Palmitoylated DNAJC5 Oligomers

Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R 

January 2023 | Journal article | eLife | Read

 

A Dual Detergent Strategy to Capture a Bacterial Outer Membrane Proteome in Peptidiscs for Characterization by Mass Spectrometry and Binding Assays

Young JW, Zhao ZY, Wason IS, van Hoa FD 

December 2022 | Journal article | Journal of Proteome Research  | Read

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“Paradoxical wakefulness” Induced by Psychedelic 5-methoxy-N, N-dimethyltryptamine in Mice

JB Bréant BJB, Mengual JP, Bannerman DM, Sharp T, Vyazovskiy VV

December 2022 | Journal article | Progress in Brain Research | Read

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Coalescing Aptamers and Liquid-Crystals for Sensing Applications

Kulabhusana PK, Ray R, Ramachandra SG, Srinivasulu M, Hariharan A, Balaji K, Mani NK

December 2022 | Journal article | Microchemical Journal | Read

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Neurons Derived from Individual Early Alzheimer's Disease Patients Reflect Their Clinical Vulnerability

Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R

November 2022 | Journal article | Brain Communications | Read

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Single-Molecule Trapping and Measurement in a Nanostructured Lipid Bilayer System

Bespalova M, Öz R, Westerlund F, Krishnan M

November 2022 | Journal article | Langmuir | Read

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Glycosylated Clusterin Species Facilitate Aβ Toxicity in Human Neurons

Foster EM, Fernandes M, Dangla-Valls A, Hublitz P, Pangalos M, Lovestone S, Ribe EM, Buckley NJ

November 2022 | Journal article | Scientific Reports | Read

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Expansion and Neofunctionalization of Actinoporin-like Genes in Mediterranean Mussel (Mytilus galloprovincialis)

Koritnik N,  Gerdol M,  Šolinc G,  Švigelj T,  Caserman S, Merzel F, Holden E,  Benesch JLP,  Trenti F, Guella G,  Pallavicini A,  Modica MV, Podobnik M, Anderluh G

November 2022 | Journal article | Genome Biology and Evolution | Read

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Anionic Lipids Unlock the Gates of Select Ion Channels in the Pacemaker Family

Schmidpeter PAM, Wu D, Rheinberger J, Riegelhaupt PM, Tang H, Robinson CV, Nimigean CM

November 2022 | Journal article | Nature Structural & Molecular Biology | Read

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Mass Spectrometry Captures Biased Signalling and Allosteric Modulation of a G-Protein-Coupled Receptor

Yen HY, Liko I, Song W, Kapoor P, Almeida F, Toporowska J, Gherbi K, Hopper JTS, Charlton S, Politis A, Sansom MSP, Jazayeri A, Robinson CV

November 2022 | Journal article | Nature Chemistry | Read

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Native Top-Down Mass Spectrometry Reveals a Role for Interfacial Glycans on Therapeutic Cytokine and Hormone Assemblies

Wu D and Robinson CV

November 2022 | Journal article | Angewandte Chemie-International Edition | Read

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CryoEM of Endogenous Mammalian V-ATPase Interacting with the TLDc Protein mEAK-7

Tan YZ , Abbas YM, Wu JZ, Wu D, Keon KA, Hesketh GG, Bueler SA, Gingras AC, Robinson CV, Grinstein S, Rubinstein JL 

November 2022 | Journal article | Life Science Alliance | Read

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Lipids Mediate Supramolecular Outer Membrane Protein Assembly in Bacteria

Webby MN, Oluwole AO, Pedebos C, Inns PG, Olerinyova A, Prakaash D, Housden NG, Benn G, Sun D, Hoogenbook BW, Kukura P, Mohammed S, Robinson CV, Khalid S, Kleanthous C

November 2022 | Journal article | Science Advances | Read

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When is a hydrophobic gate not a hydrophobic gate?

Seiferth D, Biggin PC, Tucker SJ

October 2022 | Journal article | Journal of General Physiology | Read

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Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models

Ndunge OBA, Kilian N, Salman MM

October 2022 | Journal article | Advanced Science | Read

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GPC3-Unc5 Receptor Complex Structure and Role in Cell Migration

Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, Lowe E, Ben Amar D, Zaballa S, Huo J, Pakos I, McCubbin PTN, Comoletti D, Owens RJ, Robinson CV, Castellani V, Del Toro D, Seiradake E

October 2022 | Journal article | Cell | Read

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GPR97 Triggers Inflammatory Processes in Human Neutrophils via a Macromolecular Complex Upstream of PAR2 Activation

Chu TY, Zheng-Gérard C, Huang KY, Chang YC, Chen YW, I KY, Lo YL, Chiang NY, Chen HY, Stacey M, Gordon S, Tseng WY, Sun CY, Wu YM, Pan YS, Huang CH, Lin CY, Chen TC, El Omari K, Antonelou M, Henderson SR, Salama A, Seiradake E & Lin HH

October 2022 | Journal article | Nature Communications | Read

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Neurons Derived from Individual Early Alzheimer’s Disease Patients Reflect Their Clinical Vulnerability

Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R

October 2022 | Journal article | Brain Communications | Read

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Mass Photometry Reveals SARS-CoV-2 Spike Stabilisation to Impede ACE2 Binding Through Altered Conformational Dynamics

Burnap SA, Struwe W

October 2022 | Journal article | Chemical Communications | Read

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Gain-of-function Mutations in KCNK3 Cause a Developmental Disorder with Sleep Apnea

Sörmann J, Schewe M, Proks P, Jouen-Tachoire T, Rao S, Riel EB, Agre KE, Begtrup A, Dean J, Descartes M, Fischer J, Gardham A, Lahner C, Mark PR, Muppidi S, Pichurin PN, Porrmann J, Schallner J, Smith K, Straub V, Vasudevan P, Willaert R, Carpenter EP, Rödström KEJ, Hahn MG, Müller T, Baukrowitz T, Hurles ME, Wright CF, Tucker SJ.

October 2022 | Journal article | Nature Genetics | Read

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Repressor Element 1-Silencing Transcription Factor Deficiency Yields Profound Hearing Loss Through K(v)7.4 Channel Upsurge in Auditory Neurons and Hair Cells

Zhang H, Li H, Lu M, Wang S, Ma X, Wang F, Liu J, Li X, Yang H, Zhang F, Shen H, Buckley NJ, Gamper N, Yamoah EN, Lv P

September 2022 | Journal article | eLife | Read

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Far-Field Electrostatic Signatures of Macromolecular 3D Conformation

Kloes G, Bennett TJD, Chapet-Batlle A, Behjatian A, Turberfield AJ, Krishnan M 

September 2022 | Journal article | Nano Letters | Read

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Purkinje Cell Patterning—Insights from Single-Cell Sequencing

Apsley EJ, Becker EBE

September 2022 | Journal article | Cells | Read

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Structure of the Malaria Vaccine Candidate Pfs48/45 and its Recognition by Transmission Blocking Antibodies

Ko KT, Lennartz F, Mekhaiel D, Guloglu B, Marini A, Deuker DJ, Long CA, Jore MM, Miura K, Biswas S, Higgins MK

September 2022 | Journal article | Nature Communications | Read

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Invariant Surface Glycoprotein 65 of Trypanosoma Brucei is a Complement C3 Receptor

Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M

September 2022 | Journal article | Nature Communications | Read

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Multiplex Lateral Flow Assay and the Sample Preparation Method for the Simultaneous Detection of Three Marine Toxins

Mills C, Dillon MJ, Kulabhusan PK, Senovilla-Herrero D, Campbell K

September 2022 | Journal article | Environmental Science & Technology | Read

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Direct Observation of the Molecular Mechanism Underlying Protein Polymerization

Hundt N, Cole D, Hantke MF, Miller JJ, Struwe WB, Kukura P

August 2022 | Journal article | Science Advances | Read

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Structural Basis for Proton Coupled Cystine Transport by Cystinosin

Löbel M, Salphati SP, El Omari K, Wagner A, Tucker SJ, Parker JL, Newstead S

August 2022 | Journal article | Nature Communications | Read

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Re-examining Extreme Sleep Duration in Bats: Implications for Sleep Phylogeny, Ecology, and Function

Harding CD, Yovel Y, Peirson SN, Hackett TD, Vyazovskiy VV

August 2022 | Journal article | Sleep | Read

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A new class of biological ion-driven rotary molecular motors with 5:2 symmetry

Rieu M, Krutyholowa R, Taylor NMI, Berry RM

August 2022 | Journal article | Frontiers in Microbiology | Read

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Invariant Surface Glycoprotein 65 of Trypanosoma Brucei is a Complement C3 Receptor

Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M

August 2022 | Journal article | Nature Communications | Read

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Human iPSC Co-culture Model to Investigate the Interaction between Microglia and Motor Neurons

Vahsen BF, Gray E, Candalija A, Cramb KML, Scaber J, Dafinca R, Katsikoudi A, Xu Y, Farrimond L, Wade-Martins R, James WS, Turner MR, Cowley SA, Talbot K

July 2022 | Journal article | Scientific Reports | Read

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Pathogen-sugar Interactions Revealed by Universal Saturation Transfer Analysis.

Buchanan CJ, Baldwin A, et al.

July 2022 | Journal article | Science | Read

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Influence of Effective Polarization on Ion and Water Interactions within a Biomimetic Nanopore

Phan LX, Lynch CI, Crain J, Sansom MSP, Tucker SJ 

June 2022 | Journal article | Biophysical Journal | Read

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No Association Between Amygdala Responses to Negative Faces and Depressive Symptoms: Cross-Sectional Data from 28,638 Individuals in the UK Biobank Cohort

Tamm S, Harmer CJ, Schiel J, Holub F, Rutter MK, Spiegelhalder K, Kyle SD

June 2022 | Journal article | The American Journal of Psychiatry | Read

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Patched 1 Regulates Smoothened by Controlling Sterol Binding to its Extracellular Cysteine-rich Domain

Kinnebrew M, Woolley RE, Ansell, TB, Byrne, EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey D, Siebold C, Rohatgi R

June 2022 | Journal article | Science Advances | Read

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Cryo-EM Structures of Pentameric Autoinducer-2 Exporter from Escherichia Coli Reveal its Transport Mechanism

Khera R, Mehdipour AR, Bolla JR, Kahnt J, Welsch S, Ermler U, Muenke C, Robinson CV, Hummer G, Xie H

June 2022 | Journal article | The EMBO Journal | Read

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Characterising Biomolecular Interactions and Dynamics with Mass Photometry.

Asor R and Kukura P

June 2022 | Journal article | Current Opinion in Chemical Biology | Read

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Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease.

Carlyle BC, Kitchen RR, Mattingly Z, Celia AM, Trombetta BA, Das S, Hyman BT, Kivisäkk P, Arnold SE

June 2022 | Journal article | Frontiers in Neurology | Read

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Evidence‐informed is not enough: digital therapeutics also need to be evidence‐based.

Espie CA, Firth J, Torous J

June 2022 | Journal article | World Psychiatry | Read

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Studies on enmetazobactam clarify mechanisms of widely used beta-lactamase inhibitors.

Lang PA, Raj R, Tumber A, Lohans CT, Rabe P, Robinson CV, Brem JU, Schofield CJ 

May 2022 | Journal article | Proceedings of the National Academy of Sciences of the United States of America | Read

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Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.

Burley S, Beccano-Kelly DA, Talbot K, Llana OC, Wade-Martins R 

May 2022 | Journal article | Scientific Reports | Read

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Multivalent interactions essential for lentiviral integrase function.

Ballandras-Colas A,  Chivukula V, Gruszka DT, Shan ZL, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, Taylor IA, Lyumkis D, Yardimci H, Engelman AN, Cherepanov P

May 2022 | Journal article | Nature Communications | Read

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Initiation and progression of alpha-synuclein pathology in Parkinson's disease.

Tofaris GK.

April 2022 | Journal article | Cellular and Molecular Life Sciences | Read

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Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients.

Oluwole AO, Corey RA, Brown CM, Hernandez-Rocamora VM, Stansfeld PJ, Vollmer W, Bolla JR, Robinson CV

April 2022 | Journal article | Nature Communications | Read

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Capturing a rhodopsin receptor signalling cascade across a native membrane.

Chen SY, Getter T, Salom D, Wu D, Quetschlich D, Chorev DS, Palczewski K, Robinson CV 

April 2022 | Journal article | Nature | Read

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Template-directed conjugation of heterogeneous oligonucleotides to a homobifunctional molecule for programmable supramolecular assembly.

Helmi S, Turberfield AJ 

March 2022 | Journal article | Nanoscale | Read

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Re-examining extreme sleep duration in bats: implications for sleep phylogeny, ecology, and function.

Harding CD, Yovel Y, Peirson SN, Hackett TD, Vyazovskiy VV 

March 2022 | Journal article | Sleep | Read

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Ion and water interactions with a biomimetic nanopore: molecular dynamics with effective polarization

Phan LX, Lynch CI, Crain J, Sansom MSP, Tucker SJ 

February 2022 | Journal article | Biophysical Journal | Read

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An In Vivo Fluorescence Resonance Energy Transfer-Based Imaging Platform for Targeted Drug Discovery and Cancer Therapy.

Huang SG, Jiang C, Mughal MJ, Wang GY, Xing FQ

February 2022 | Journal article | Frontiers in Bioengineering and Biotechnology | Read

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Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.

Ragotte RJ, Pulido D, Lias AM, Quinkert D, Alanine DGW, Jamwal A, Davies H, Nacer A, Lowe ED, Grime G, Illingworth J, Donat, RF, Garman EF, Bowyer, PW, Higgins MK, Draper SJ

February 2022 | Journal article | Nature Communications | Read

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Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex.

Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu XY, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA

January 2022 | Journal article | Science | Read

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Ion currents through Kir potassium channels are gated by anionic lipids.

Jin RT, He ST, Black KA, Clarke OB, Wu D, Bolla JR, Johnson P, Periasamy A, Wardak A, Czabotar P, Colman PM, Robinson CV, Laver D, Smith BJ, Gulbis JM 

January 2022 | Journal article | Nature Communications | Read

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Recent breakthroughs and future directions in drugging aquaporins.

Salman MM, Kitchen P, Yool AJ, Bill RM

January 2022 | Journal article | Trends in Pharmacological Sciences | Read

Molecular basis for redox control by the human cystine/glutamate antiporter system xc.

Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S

December 2021 | Journal article | Nature Communications | Read

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Biallelic PI4KA variants cause neurological, intestinal and immunological disease

Salter CG, Cai Y, Lo B, Helman G, Taylor H, McCartney A, Leslie JS, Accogli A, Zara F, Traverso M, Fasham J, Lees JA, Ferla MP, Chioza BA, Wenger O, Scott E, Cross HE, Crawford J, Warshawsky I, Keisling M, Agamanolis D, Melver CW, Cox H, Elawad M, Marton T, Wakeling MN, Holzinger D, Tippelt S, Munteanu M, Valcheva D, Deal C, Van Meerbeke S, Vockley CW, Butte M, Acar U, van der Knaap MS, Korenke GC, Kotzaeridou U, Balla T, Simons C, Uhlig HH, Crosby AH, De Camilli P, Wolf NI, Baple EL

December 2021 | Journal article | Brain | Read

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Break-ups and make-ups: DNA search and repair.

Lalande E, El Sayyed H

December 2021 | Journal article | Nature Reviews Microbiology | Read

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Multiplexed Profiling of Extracellular Vesicles for Biomarker Development.

Jiang C, Fu Y, Liu G, Shu B, Davis J, Tofaris GK

December 2021 | Journal article | Nano-Micro Letters | Read

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Acyl carrier protein promotes MukBEF action in Escherichia coli chromosome organization-segregation.

Prince JP, Bolla JR, Fisher GLM, Mäkelä J, Fournier M, Robinson CV, Arciszewska LK, Sherratt DJ

November 2021 | Journal article | Nature Communications | Read

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Single molecule mass photometry reveals the dynamic oligomerization of human and plant peroxiredoxins.

Liebthal M, Kushwah MS, Kukura P, Dietz K-J

November 2021 | Journal article | iScience | Read

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Effects of ionic strength on gating and permeation of TREK-2 K2P channels

Conrad LJ, Proks P, Tucker SJ

October 2021 | Journal article | Plos One | Read

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Mass spectrometry informs the structure and dynamics of membrane proteins involved in lipid and drug transport.

Bolla JR, Fiorentino F, Robinson CV

October 2021 | Journal article | Current Opinion in Structural Biology | Read

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Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target

Adams O, Deme JC, Parker JL, Fowler PW, Lea SM, Newstead S

October 2021 | Journal article | Structure | Read

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Structural Basis for Silicic Acid Uptake by Higher Plants.

van den Berg B, Pedebos C, Bolla JR, Robinson CV, Baslé A, Khalid S

September 2021 | Journal article | Journal of Molecular Biology | Read

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Molecular basis for redox control by the human cystine/glutamate antiporter System xc-

Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S

August 2021 | Journal article | Read

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Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals.

Parker JL, Deme JC, Wu Z, Kuteyi G, Huo J, Owens RJ, Biggin PC, Lea SM, Newstead S

August 2021 | Journal article | Science Advances | Read

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The molecular basis of regulation of bacterial capsule assembly by Wzc.

Yang Y, Liu J, Clarke BR, Seidel L, Bolla JR, Ward PN, Zhang P, Robinson CV, Whitfield C, Naismith JH

July 2021 | Journal article | Nature Communications | Read

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Structural basis of antifolate recognition and transport by PCFT.

Parker JL, Deme JC, Kuteyi G, Wu Z, Huo J, Goldman ID, Owens RJ, Biggin PC, Lea SM, Newstead S

July 2021 | Journal article | Nature | Read

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Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target.

Adams O, Deme JC, Parker JL, CRyPTIC Consortium, Fowler PW, Lea SM, Newstead S

June 2021 | Journal article | Structure | Read

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Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons.

Tanudjojo B, Shaikh SS, Fenyi A, Bousset L, Agarwal D, Marsh J, Zois C, Heman-Ackah S, Fischer R, Sims D, Melki R, Tofaris GK

June 2021 | Journal article | Nature Communications | Read

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The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase.

Kaur H, Jakob RP, Marzinek JK, Green R, Imai Y, Bolla JR, Agustoni E, Robinson CV, Bond PJ, Lewis K, Maier T, Hiller S

May 2021 | Journal article | Nature | Read