Publications
Physical-Property-Based Patterning: Simply Engineering Complex Tissues
Zlotnick HM, Stevens MM, Mauck RL
September 2024 | Journal article | Trends in Biotechnology | Read
Natural Malaria Infection Elicits Rare but Potent Neutralizing Antibodies to the Blood-Stage Antigen RH5
Wang LT, Cooper AJR, Farrell B, Miura K, Diouf A, Müller-Sienerth N, Crosnier C, Purser L, Kirtley PJ, Maciuszek M, Barrett JR, McHugh K, Ogwang R, Tucker C, Li S, Doumbo S, Doumtabe D, Pyo CW, Skinner J, Nielsen CM, Silk SE, Kayentao K, Ongoiba A, Zhao M, Nguyen DC, Lee FE, Minassian AM, Geraghty DE, Traore B, Seder RA, Wilder BK, Crompton PD, Wright GJ, Long CA, Draper SJ, Higgins MK, Tan J
September 2024 | Journal article | Cell | Read
Analysis Of the Diverse Antigenic Landscape of The Malaria Protein RH5 Identifies A Potent Vaccine-Induced Human Public Antibody Clonotype
Barrett JR, Pipini D, Wright ND, Cooper AJR, Gorini G, Quinkert D, Lias AM, Davies H, Rigby CA, Aleshnick M, Williams BG, Bradshaw WJ, Paterson NG, Martinson T, Kirtley P, Picard L, Wiggins CD, Donnellan FR, King LDW, Wang LT, Popplewell JF, Silk SE, de Ruiter Swain J, Skinner K, Kotraiah V, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Minassian AM, Lauffenburger DA, Miura K, Long CA, Wilder BK, Koekemoer L, Tan J, Nielsen CM, McHugh K, Draper SJ
September 2024 | Journal article | Cell | Read
Variant-Specific Effects of GBA1 Mutations on Dopaminergic Neuron Proteostasis
Onal G, Yalçın-Çakmaklı G, Özçelik CE, Boussaad I, Şeker UÖŞ, Fernandes HJR, Demir H, Krüger R, Elibol B, Dökmeci S, Salman MM
September 2024 | Journal article | Journal of Neurochemistry | Read
Light Sampling Behaviour Regulates Circadian Entrainment in Mice
Steel LCE, Tam SKE, Brown LA, Foster RG, Peirson SN
September 2024 | Journal article | BMC Biology | Read
Engineering Stress as a Motivation for Filamentous Virus Morphology
McMahon A, Vijayakrishnan S, El Sayyed H, Groves D, Conley MJ, Hutchinson E, Robb NC
September 2024 | Journal article | Biophysical Reports | Read
Blood-Stage Malaria Vaccine Candidate RH5.1/Matrix-M in Healthy Tanzanian Adults and Children; An Open-Label, Non-Randomised, First-in-Human, Single-Centre, Phase 1b Trial
Silk SE, Kalinga WF, Salkeld J, Mtaka IM, Ahmed S, Milando F, Diouf A, Bundi CK, Balige N, Hassan O, Mkindi CG, Rwezaula S, Athumani T, Mswata S, Lilolime NS, Simon B, Msami H, Mohamed M, David DM, Mohammed L, Nyaulingo G, Mwalimu B, Juma O, Mwamlima TG, Sasamalo IA, Mkumbange RP, Kamage JJ, Barrett JR, King LDW, Hou MM, Pulido D, Carnrot C, Lawrie AM, Cowan RE, Nugent FL, Roberts R, Cho JS, Long CA, Nielsen CM, Miura K, Draper SJ, Olotu AI, Minassian AM
September 2024 | Journal article | The Lancet Infectious Diseases | Read
A Bioorthogonal Precision Tool for Human N-Acetylglucosaminyltransferase V
Liu Y, Bineva-Todd G, Meek RW, Mazo L, Piniello B, Moroz O, Burnap SA, Begum N, Ohara A, Roustan C, Tomita S, Kjaer S, Polizzi K, Struwe WB, Rovira C, Davies GJ, Schumann B
September 2024 | Journal article | Journal of the American Chemical Society | Read
A Facile Method to Quantify Synthetic Peptide Concentrations on Biomaterials
Wojciechowski JP, Benge T, Chen K, Echalier C, Xie R, Stevens MM
September 2024 | Journal article | ACS Applied Materials & Interfaces | Read
Oligomerization-Driven Avidity Correlates with SARS-CoV-2 Cellular Binding and Inhibition
Asor R, Olerinyova A, Burnap SA, Kushwah MS, Soltermann F, Rudden LSP, Hensen M, Vasiljevic S, Brun J, Hill M, Chang L, Dejnirattisai W, Supasa P, Mongkolsapaya J, Zhou D, Stuart DI, Screaton GR, Degiacomi MT, Zitzmann N, Benesch JLP, Struwe WB, Kukura P
September 2024 | Journal article | PNAS | Read
Plug and Play Virus-like Particles for the Generation of Anti-toxin Antibodies
Edge RJ, Marriott AE, Stars EL, Patel RN, Wilkinson MC, King LDW, Slagboom J, Tan CH, Ratanabanangkoon K, Draper SJ, Ainsworth S
September 2024 | Journal article | Toxicon: X | Read
Rapid Identification of Bacterial Isolates Using Microfluidic Adaptive Channels and Multiplexed Fluorescence Microscopy
Chatzimichail S, Turner P, Feehily C, Farrar A, Crook D, Andersson M, Oakley S, Barrett L, El Sayyed H, Kyropoulos J, Nellåker C, Stoesser N, Kapanidis AN
September 2024 | Journal article | Lab on a Chip | Read
Rational Structure-Guided Design of a Blood Stage Malaria Vaccine Immunogen Presenting a Single Epitope from PfRH5
Harrison TE, Alam N, Farrell B, Quinkert D, Lias AM, King LDW, Barfod LK, Draper SJ, Campeotto I, Higgins MK
September 2024 | Journal article | EMBO Molecular Medicine | Read
Sensing the Structural and Conformational Properties of Single-Stranded Nucleic Acids Using Electrometry and Molecular Simulations
Walker-Gibbons R, Zhu X, Behjatian A, Bennett TJD, Krishnan M
September 2024 | Journal article | Scientific Reports | Read
Fillable Magnetic Microrobots for Drug Delivery to Cardiac Tissues In Vitro
Chen MS, Sun R, Wang R, Zuo Y, Zhou K, Kim J, Stevens MM
September 2024 | Journal article | Advanced Healthcare Materials | Read
Oscillatory-Quality of Sleep Spindles Links Brain State with Sleep Regulation and Function
Blanco-Duque C, Bond SA, Krone LB, Dufour JP, Gillen ECP, Purple RJ, Kahn MC, Bannerman DM, Mann EO, Achermann P, Olbrich E, Vyazovskiy VV
September 2024 | Journal article | Science Advances | Read
Ablation of Oligodendrogenesis in Adult Mice Alters Brain Microstructure and Activity Independently of Behavioral Deficits
Kaller MS, Lazari A, Feng Y, van der Toorn A, Rühling S, Thomas CW, Shimizu T, Bannerman D, Vyazovskiy V, Richardson WD, Sampaio-Baptista C, Johansen-Berg H
September 2024 | Journal article | Glia | Read
Author Correction: Covalent Penicillin-protein Conjugates Elicit Anti-drug Antibodies that are Clonally and Functionally Restricted
Deimel LP, Moynié L, Sun G, Lewis V, Turner A, Buchanan CJ, Burnap SA, Kutuzov M, Kobras CM, Demyanenko Y, Mohammed S, Stracy M, Struwe WB, Baldwin AJ, Naismith J, Davis BG, Sattentau QJ
September 2024 | Journal article | Nature Communications | Read
Molecular Basis of TMED9 Oligomerization and Entrapment of Misfolded Protein Cargo in the Early Secretory Pathway
Xiao L, Pi X, Goss AC, El-Baba T, Ehrmann JF, Grinkevich E, Bazua-Valenti S, Padovano V, Alper SL, Carey D, Udeshi ND, Carr SA, Pablo JL, Robinson CV, Greka A, Wu H
September 2024 | Journal article | Science Advances | Read
Location and Function of TDP-43 in Platelets, Alterations in Neurodegenerative Diseases and Arising Considerations for Current Plasma Biobank Protocols
Luthi-Carter R, Cappelli S, Le Roux-Bourdieu M, Tentillier N, Quinn JP, Petrozziello T, Gopalakrishnan L, Sethi P, Choudhary H, Bartolini G, Gebara E, Stuani C, Font L, An J, Ortega V, Sage J, Kosa E, Trombetta BA, Simeone R, Seredenina T, Afroz T, Berry JD, Arnold SE, Carlyle BC, Adolfsson O, Sadri-Vakili G, Buratti E, Bowser R, Agbas A
September 2024 | Journal article | Scientific Reports | Read
Practical Advice on Measuring and Applying Light for Laboratory Mammals.
Lucas RJ, Peirson SN
August 2024 | Journal article | Journal of Biological Rhythms | Read
Native MS-guided Lipidomics to Define Endogenous Lipid Microenvironments of Eukaryotic Receptors and Transporters
Wu D, Tang H, Qiu X, Song S, Chen S, Robinson CV
August 2024 | Journal article | Nature Protocols | Read
Lifting the Concentration Limit of Mass Photometry by PEG Nanopatterning
Kratochvíl J, Asor R, Helmi S, Struwe WB, Kukura P
August 2024 | Journal article | Nano Letters | Read
Biological Effects of Sodium Phenylbutyrate and Taurursodiol in Alzheimer's Disease
Knowlton N, Williams VJ, Burns JM, Crane M, McManus AJ, Vaishnavi SN, Arvanitakis Z, Neugroschl J, Bell K, Trombetta BA, Carlyle BC, Kivisäkk P, Dodge HH, Tanzi RE, Yeramian PD, Leslie K
August 2024 | Journal article | Alzheimer’s Association | Read
Covalent Penicillin-protein Conjugates Elicit Anti-drug Antibodies that are Clonally and Functionally Restricted
Deimel LP, Moynié L, Sun G, Lewis V, Turner A, Buchanan CJ, Burnap SA, Kutuzov M, Kobras CM, Demyaneko Y, Mohammed S, Stracy M, Struwe WB, Baldwin AJ, Naismith J, Davis BG, Sattentau QJ
August 2024 | Journal article | Nature Communications | Read
Infection Inspection: Using the Power of Citizen Science for Image-based Prediction of Antibiotic Resistance in Escherichia Coli Treated with Ciprofloxacin
Farrar A, Feehily C, Turner P, Zagajewski A, Chatzimichail S, Crook D, Andersson M, Oakley S, Barrett L, El Sayyed H, Fowler PW, Nellåker C, Kapanidis AN, Stoesser N
August 2024 | Journal article | Scientific Reports | Read
ATAXIN-2 Intermediate-length Polyglutamine Expansions Elicit ALS-associated Metabolic and Immune Phenotypes
Vieira de Sá R, Sudria-Lopez E, Cañizares Luna M, Harschnitz O, van den Heuvel DMA, Kling S, Vonk D, Westeneng HJ, Karst H, Bloemenkamp L, Varderidou-Minasian S, Schlegel DK, Mars M, Broekhoven MH, van Kronenburg NCH, Adolfs Y, Vangoor VR, de Jongh R, Ljubikj T, Peeters L, Seeler S, Mocholi E, Basak O, Gordon D, Giuliani F, Verhoeff T, Korsten G, Calafat Pla T, Venø MT, Kjems J, Talbot K, van Es MA, Veldink JH, van den Berg LH, Zelina P, Pasterkamp RJ
August 2024 | Journal article | Nature communications | Read
Using Matrix Assisted Laser Desorption Ionisation Mass Spectrometry Combined with Machine Learning for Vaccine Authenticity Screening
Clarke R, Bharucha T, Arman BY, Gangadharan B, Gomez Fernandez L, Mosca S, Lin Q, Van Assche K, Stokes R, Dunachie S, Deats M, Merchant HA, Caillet C, Walsby-Tickle J, Probert F, Matousek P, Newton PN, Zitzmann N, McCullagh JSO
August 2024 | Journal article | Npj Vaccines | Read
Analysis of the Diverse Antigenic Landscape of the Malaria Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype
Barrett JR, Pipini D, Wright ND, Cooper AJR, Gorini G, Quinkert D, Lias AM, Davies H, Rigby CA, Aleshnick M, Williams BG, Bradshaw WJ, Paterson NG, Martinson T, Kirtley P, Picard L, Wiggins CD, Donnellan FR, King LDW, Wang LT, Popplewell JF, Silk SE, de Ruiter Swain J, Skinner K, Kotraiah V, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Minassian AM, Lauffenburger DA, Miura K, Long CA, Wilder BK, Koekemoer L, Tan J, Nielsen CM, McHugh K, Draper SJ
July 2024 | Journal article | Cell | Read
Natural Malaria Infection Elicits Rare but Potent Neutralizing Antibodies to the Blood-stage Antigen RH5
Wang LT, Cooper AJR, Farrell B, Miura K, Diouf A, Müller-Sienerth N, Crosnier C, Purser L, Kirtley PJ, Maciuszek M, Barrett JR, McHugh K, Ogwang R, Tucker C, Li S, Doumbo S, Doumtabe D, Pyo CW, Skinner J, Nielsen CM, Silk SE, Kayentao K, Ongoiba A, Zhao M, Nguyen DC, Lee FE, Minassian AM, Geraghty DE, Traore B, Seder RA, Wilder BK, Crompton PD, Wright GJ, Long CA, Draper SJ, Higgins MK, Tan J
July 2024 | Journal article | Cell | Read
Ablation of Oligodendrogenesis in Adult Mice Alters Brain Microstructure and Activity Independently of Behavioral Deficits
Kaller MS, Lazari A, Feng Y, van der Toorn A, Rühling S, Thomas CW, Shimizu T, Bannerman D, Vyazovskiy V, Richardson WD, Sampaio-Baptista C, Johansen-Berg H
July 2024 | Journal article | Glia | Read
Preclinical Development of a Stabilized RH5 Virus-like Particle Vaccine that Induces Improved Antimalarial Antibodies
King LDW, Pulido D, Barrett JR, Davies H, Quinkert D, Lias AM, Silk SE, Pattinson DJ, Diouf A, Williams BG, McHugh K, Rodrigues A, Rigby CA, Strazza V, Suurbaar J, Rees-Spear C, Dabbs RA, Ishizuka AS, Zhou Y, Gupta G, Jin J, Li Y, Carnrot C, Minassian AM, Campeotto I, Fleishman SJ, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Long CA, Miura K, Ashfield R, Skinner K, Howarth MR, Biswas S, Draper SJ
July 2024 | Journal article | Cell Reports Medicine | Read
A Chemical Reaction Network Drives Complex Population Dynamics in Oscillating Self-Reproducing Vesicles
Zhang Z, Howlett MG, Silvester E, Kukura P, Fletcher SP
July 2024 | Journal article | Journal of the American Chemical Society | Read
The Mechanism of Mammalian Proton-Coupled Peptide Transporters
Lichtinger SM, Parker JL, Newstead S, Biggin PC
July 2024 | Journal article | ELife | Read
Recent Insights from Human Induced Pluripotent Stem Cell Models into the Role of Microglia in Amyotrophic Lateral Sclerosis
Nikel LM, Talbot K, Vahsen BF
July 2024 | Journal article | BioEssays | Read
Lifting the Concentration Limit of Mass Photometry by PEG Nanopatterning
Kratochvíl J, Asor R, Helmi S, Struwe WB, Kukura P
July 2024 | Journal article | Nano Letters | Read
Molecular Basis for pH Sensing in the KDEL Trafficking Receptor
Wu Z, Smith K, Gerondopoulos A, Sobajima T, Parker JL, Barr FA, Newstead S, Biggin PC
July 2024 | Journal article | Structure | Read
Functional Diversity Among Cardiolipin Binding Sites on the Mitochondrial ADP/ATP Carrier
Senoo N, Chinthapalli DK, Baile MG, Golla VK, Saha B, Oluwole AO, Ogunbona OB, Saba JA, Munteanu T, Valdez Y, Whited K, Sheridan MS, Chorev D, Alder NN, May ER, Robinson CV, Claypool SM
July 2024 | Journal article | The EMBO Journal | Read
Astrocytes in Functional Recovery Following Central Nervous System Injuries
Alhadidi QM, Bahader GA, Arvola O, Kitchen P, Shah ZA, Salman MM
July 2024 | Journal article | The Journal of Physiology | Read
Methods to Estimate Body Temperature and Energy Expenditure Dynamics in Fed and Fasted Laboratory Mice: Effects of Sleep Deprivation and Light Exposure
van der Vinne V, McKillop LE, Wilcox SL, Cantley J, Peirson SN, Swoap SJ, Vyazovskiy VV
June 2024 | Journal article | Journal of Comparative Physiology B | Read
Phage Defence System CBASS is Regulated by a Prokaryotic E2 Enzyme that Imitates the Ubiquitin Pathway
Yan Y, Xiao J, Huang F, Xian W, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D, Liu X, Wang L, Zhu B
June 2024 | Journal article | Nature Microbiology | Read
ROS-Dependent S-palmitoylation Activates Cleaved and Intact Gasdermin D
Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H
June 2024 | Journal article | Nature | Read
A Chemical Reaction Network Drives Complex Population Dynamics in Oscillating Self-Reproducing Vesicles
Zhang Z, Howlett MG, Silvester E, Kukura P, Fletcher SP
June 2024 | Journal article | Journal of the American Chemical Society | Read
Blood-stage Malaria Vaccine Candidate RH5.1/Matrix-M in Healthy Tanzanian Adults and Children; an Open-label, Non-randomised, First-in-human, Single-centre, Phase 1b Trial
Silk SE, Kalinga WF, Salkeld J, Mtaka IM, Ahmed S, Milando F, Diouf A, Bundi CK, Balige N, Hassan O, Mkindi CG, Rwezaula S, Athumani T, Mswata S, Lilolime NS, Simon B, Msami H, Mohamed M, David DM, Mohammed L, Nyaulingo G, Mwalimu B, Juma O, Mwamlima TG, Sasamalo IA, Mkumbange RP, Kamage JJ, Barrett JR, King LDW, Hou MM, Pulido D, Carnrot C, Lawrie AM, Cowan RE, Nugent FL, Roberts R, Cho JS, Long CA, Nielsen CM, Miura K, Draper SJ, Olotu AI, Minassian AM
June 2024 | Journal article | The Lancet Infectious Diseases | Read
Development of an Improved Blood-stage Malaria Vaccine Targeting the Essential RH5-CyRPA-RIPR Invasion Complex
Williams BG, King LDW, Pulido D, Quinkert D, Lias AM, Silk SE, Ragotte RJ, Davies H, Barrett JR, McHugh K, Rigby CA, Alanine DGW, Barfod L, Shea MW, Cowley LA, Dabbs RA, Pattinson DJ, Douglas AD, Lyth OR, Illingworth JJ, Jin J, Carnrot C, Kotraiah V, Christen JM, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Skinner K, Miura K, Long CA, Higgins MK, Draper SJ
June 2024 | Journal article | Nature Communications | Read
Functional Diversity Among Cardiolipin Binding Sites on the Mitochondrial ADP/ATP Carrier
Senoo N, Chinthapalli DK, Baile MG, Golla VK, Saha B, Oluwole AO, Ogunbona OB, Saba JA, Munteanu T, Valdez Y, Whited K, Sheridan MS, Chorev D, Alder NN, May ER, Robinson CV, Claypool SM
June 2024 | Journal article | The EMBO Journal | Read
Cellular and Axonal Transport Phenotypes due to the C9ORF72 HRE in iPSC Motor and Sensory Neurons
Scaber J, Thomas-Wright I, Clark AJ, Xu Y, Vahsen BF, Carcolé M, Dafinca R, Farrimond L, Isaacs AM, Bennett DL, Talbot K
June 2024 | Journal article | Stem Cell Reports | Read
Body Weight Modulates the Impact of Oxytocin on Chronic Cold-immobilization Stress Response
Önal D, Korkmaz H, Önal G, Pehlivanoğlu B
June 2024 | Journal article | Peptites | Read
Structural Basis for IL-33 Recognition and its Antagonism by the Helminth Effector Protein HpARI2
Jamwal A, Colomb F, McSorley HJ, Higgins MK
June 2024 | Journal article | Nature Communications | Read
Plasma VEGFA and PGF Impact Longitudinal Tau and Cognition in Preclinical Alzheimer's Disease
Yang HS, Yau WW, Carlyle BC, Trombetta BA, Zhang C, Shirzadi Z, Schultz AP, Pruzin JJ, Fitzpatrick CD, Kirn DR, Rabin JS, Buckley RF, Hohman TJ, Rentz DM, Tanzi RE, Johnson KA, Sperling RA, Arnold SE, Chhatwal JP
June 2024 | Journal article | Brain | Read
Paired Plasma Lipidomics and Proteomics Analysis in the Conversion from Mild Cognitive Impairment to Alzheimer's Disease
Gómez-Pascual A, Naccache T, Xu J, Hooshmand K, Wretlind A, Gabrielli M, Lombardo MT, Shi L, Buckley NJ, Tijms BM, Vos SJB, Ten Kate M, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, Popp J, Martinez-Lage P, Streffer J, Barkhof F, Zetterberg H, Visser PJ, Lovestone S, Bertram L, Nevado-Holgado AJ, Gualerzi A, Picciolini S, Proitsi P, Verderio C, Botía JA, Legido-Quigley C
May 2024 | Journal article | Computers in Biology and Medicine | Read
Ultrasonic Vocalisation Rate Tracks the Diurnal Pattern of Activity in Winter Phenotype Djungarian Hamsters (Phodopus sungorus)
Harding CD, Walker KMM, Hackett TD, Herwig A, Peirson SN, Vyazovskiy VV
May 2024 | Journal article | Journal of Comparative Physiology B | Read
Extracellular Modulation of TREK-2 Activity with Nanobodies Provides Insight into the Mechanisms of K2P Channel Regulation
Rödström KEJ, Cloake A, Sörmann J, Baronina A, Smith KHM, Pike ACW, Ang J, Proks P, Schewe M, Holland-Kaye I, Bushell SR, Elliott J, Pardon E, Baukrowitz T, Owens RJ, Newstead S, Steyaert J, Carpenter EP, Tucker SJ
May 2024 | Journal article | Nature Communications | Read
Evaluation of the Precision of the Plasmodium Knowlesi Growth Inhibition Assay for Plasmodium Vivax Duffy-binding Protein-based Malaria Vaccine Development
Mertens JE, Rigby CA, Bardelli M, Quinkert D, Hou MM, Diouf A, Silk SE, Chitnis CE, Minassian AM, Moon RW, Long CA, Draper SJ, Miura K
May 2024 | Journal article | Vaccine | Read
An ALS-associated Mutation Dysregulates Microglia-derived Extracellular MicroRNAs in a Sex-specific Manner
Christoforidou E, Moody L, Joilin G, Simoes FA, Gordon D, Talbot K, Hafezparast M
May 2024 | Journal article | Disease Models and Mechanisms | Read
BERNN: Enhancing Classification of Liquid Chromatography Mass Spectrometry Data with Batch Effect Removal Neural Networks
Pelletier SJ, Leclercq M, Roux-Dalvai F, de Geus MB, Leslie S, Wang W, Lam TT, Nairn AC, Arnold SE, Carlyle BC, Precioso F, Droit A
May 2024 | Journal article | Nature Communications | Read
Recent Insights from Human Induced Pluripotent Stem Cell Models into the Role of Microglia in Amyotrophic Lateral Sclerosis
Nikel LM, Talbot K, Vahsen BF
May 2024 | Journal article | BioEssays | Read
Fillable Magnetic Microrobots for Drug Delivery to Cardiac Tissues In Vitro
Chen MS, Sun R, Wang R, Zuo Y, Zhou K, Kim J, Stevens MM
May 2024 | Journal article | Advanced Healthcare Materials | Read
4D Multimaterial Printing of Soft Actuators with Spatial and Temporal Control
Zhou K, Sun R, Wojciechowski JP, Wang R, Yeow J, Zuo Y, Song X, Wang C, Shao Y, Stevens MM
May 2024 | Journal article | Advanced Materials | Read
The Complete Assembly of Human LAT1-4F2hc Complex Provides Insights into its Regulation, Function and Localisation
Wu D, Yan R, Song S, Swansiger AK, Li Y, Prell JS, Zhou Q, Robinson CV
May 2024 | Journal article | Nature Communications | Read
Methods to Estimate Body Temperature and Energy Expenditure Dynamics in Fed and Fasted Laboratory Mice: Effects of Sleep Deprivation and Light Exposure
van der Vinne V, McKillop LE, Wilcox SL, Cantley J, Peirson SN, Swoap SJ, Vyazovskiy VV
April 2024 | Journal article | Journal of Comparative Physiology | Read
3,4-Ethylenedioxythiophene Hydrogels: Relating Structure and Charge Transport in Supramolecular Gels
Salter LCB, Wojciechowski JP, McLean B, Charchar P, Barnes PRF, Creamer A, Doutch J, Barriga HMG, Holme MN, Yarovsky I, Stevens MM
April 2024 | Journal article | Chemistry of Materials | Read
Phage Defence System CBASS is Regulated by a Prokaryotic E2 Enzyme that Imitates the Ubiquitin Pathway
Yan Y, Xiao J, Huang F, Xian W, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D, Liu X, Wang L, Zhu B
April 2024 | Journal article | Nature Microbiology | Read
Variant-specific Effects of GBA1 Mutations on Dopaminergic Neuron Proteostasis
Onal G, Yalçın-Çakmaklı G, Özçelik CE, Boussaad I, Şeker UÖŞ, Fernandes HJR, Demir H, Krüger R, Elibol B, Dökmeci S, Salman MM
April 2024 | Journal article | Journal of Neurochemistry | Read
A Charge-dependent Long-ranged Force Drives Tailored Assembly of Matter in Solution
Wang S, Walker-Gibbons R, Watkins B, Flynn M, Krishnan M
April 2024 | Journal article | Nature Nanotechnology | Read
Detergents with Scalable Properties Identify Noncanonical Lipopolysaccharide Binding to Bacterial Inner Membrane Proteins
Urner LH, Fiorentino F, Shutin D, Sauer JB, Agasid MT, El-Baba TJ, Bolla JR, Stansfeld PJ, Robinson CV
April 2024 | Journal article | Journal of the American Chemical Society | Read
Molecular Mechanism of Complement Inhibition by the Trypanosome Receptor ISG65
Cook AD, Carrington M, Higgins MK
April 2024 | Journal article | Elife | Read
Emergence of Fractal Geometries in the Evolution of a Metabolic Enzyme
Sendker FL, Lo YK, Heimerl T, Bohn S, Persson LJ, Mais CN, Sadowska W, Paczia N, Nußbaum E, Del Carmen Sánchez Olmos M, Forchhammer K, Schindler D, Erb TJ, Benesch JLP, Marklund EG, Bange G, Schuller JM, Hochberg GKA
April 2024 | Journal article | Nature | Read
Molecular Basis for pH Sensing in the KDEL Trafficking Receptor
Wu Z, Smith K, Gerondopoulos A, Sobajima T, Parker JL, Barr FA, Newstead S, Biggin PC
April 2024 | Journal article | Structure | Read
Physical-property-based Patterning: Simply Engineering Complex Tissues
Zlotnick HM, Stevens MM, Mauck RL
April 2024 | Journal article | Trends in Biotechnology | Read
Phospholipids Differentially Regulate Ca2+ Binding to Synaptotagmin-1
Lawrence SAS, Kirschbaum C, Bennett JL, Lutomski CA, El-Baba TJ, Robinson CV
April 2024 | Journal article | ACS Chemical Biology | Read
CRISPRi: A Way to Integrate iPSC-derived Neuronal Models
Franks SNJ, Heon-Roberts R, Ryan BJ
April 2024 | Journal article | Biochemical Society Transactions | Read
Microneedle-mediated Nanomedicine to Enhance Therapeutic and Diagnostic Efficacy
Zuo Y, Sun R, Del Piccolo N, Stevens MM
April 2024 | Journal article | Nano Convergence | Read
Future Opportunities in Solute Carrier Structural Biology
Newstead S
April 2024 | Journal article | Nature Structural & Molecular Biology | Read
ROS-dependent S-palmitoylation Activates Cleaved and Intact Gasdermin D
Du G, Healy LB, David L, Walker C, El-Baba TJ, Lutomski CA, Goh B, Gu B, Pi X, Devant P, Fontana P, Dong Y, Ma X, Miao R, Balasubramanian A, Puthenveetil R, Banerjee A, Luo HR, Kagan JC, Oh SF, Robinson CV, Lieberman J, Wu H
April 2024 | Journal article | Nature | Read
Single-protein Optical Holography
Thiele, J.C., Pfitzner, E. & Kukura, P
March 2024 | Journal article | Nature Photonics | Read
Recommendations for Measuring and Standardizing Light for Laboratory Mammals to Improve Welfare and Reproducibility in Animal Research
Lucas RJ, Allen AE, Brainard GC, Brown TM, Dauchy RT, Didikoglu A, Do MTH, Gaskill BN, Hattar S, Hawkins P, Hut RA, McDowell RJ, Nelson RJ, Prins JB, Schmidt TM, Takahashi JS, Verma V, Voikar V, Wells S, Peirson SN
March 2024 | Journal article | PLOS Biology | Read
A Charge-dependent Long-ranged Force Drives Tailored Assembly of Matter in Solution
Wang S, Walker-Gibbons R, Watkins B, Flynn M, Krishnan M
March 2024 | Journal article | Nature Nanotechnology | Read
Interrogation of the Human Cortical Peptidome Uncovers Cell-type Specific Signatures of Cognitive Resilience Against Alzheimer's Disease
Morgan GR, Carlyle BC
March 2024 | Journal article | Scientific Reports | Read
Myosin-5 Caries its Step Length to Carry Cargo Straight Along the Irregular F-actin Track
Fineberg A, Takagi Y, Thirumurugan K, Andrecka J, Billington N, Young G, Cole D, Burgess SA, Curd AP, Hammer JA, Sellers JR, Kukura P, Knight PJ
March 2024 | Journal article | PNAS | Read
Body Weight Modulates the Impact of Oxytocin on Chronic Cold-Immobilization Stress Response
Önal D, Korkmaz H, Önal G, Pehlivanoğlu B
March 2024 | Journal article | Peptides | Read
Real-Time Biosynthetic Reaction Monitoring Informs the Mechanism of Action of Antibiotics
Oluwole AO, Hernández-Rocamora VM, Cao Y, Li X, Vollmer W, Robinson CV, Bolla JR
March 2024 | Journal article | Journal of the American Chemical Society | Read
Repurposing Rapid Diagnostic Tests to Detect Falsified Vaccines in Supply Chains
Bharucha T, Gangadharan B, Clarke R, Fernandez LG, Arman BY, Walsby-Tickle J, Deats M, Mosca S, Lin Q, Stokes R, Dunachie S, Merchant HA, Dubot-Pérès A, Caillet C, McCullagh J, Matousek P, Zitzmann N, Newton PN
March 2024 | Journal article | Vaccine | Read
A Single Nuclear Transcriptomic Characterisation of Mechanisms Responsible for Impaired Angiogenesis and Blood-brain Barrier Function in Alzheimer's Disease
Tsartsalis S, Sleven H, Fancy N, Wessely F, Smith AM, Willumsen N, Cheung TKD, Rokicki MJ, Chau V, Ifie E, Khozoie C, Ansorge O, Yang X, Jenkyns MH, Davey K, McGarry A, Muirhead RCJ, Debette S, Jackson JS, Montagne A, Owen DR, Miners JS, Love S, Webber C, Cader MZ, Matthews PM
March 2024 | Journal article | Nature Communications | Read
Ion Mobility-tandem Mass Spectrometry of Mucin-type O-glycans
Bechtella L, Chunsheng J, Fentker K, Ertürk GR, Safferthal M, Polewski Ł, Götze M, Graeber SY, Vos GM, Struwe WB, Mall MA, Mertins P, Karlsson NG, Pagel K
March 2024 | Journal article | Nature Communications | Read
CRISPRi: A Way to Integrate iPSC-derived Neuronal Models
Franks SNJ, Heon-Roberts R, Ryan BJ
March 2024 | Journal article | Biochemical Society Transactions | Read
Single-cell Spatial Transcriptomic and Translatomic Profiling of Dopaminergic Neurons in Health, Aging, and Disease
Kilfeather P, Khoo JH, Wagner K, Liang H, Caiazza MC, An Y, Zhang X, Chen X, Connor-Robson N, Shang Z, Wade-Martins R
March 2024 | Journal article | Cell Reports | Read
Coarse-grained Modeling of DNA-RNA Hybrids.
Ratajczyk EJ, Šulc P, Turberfield AJ, Doye JPK, Louis AA
March 2024 | Journal article | The Journal of Chemical Physics | Read
Plasma VEGFA and PGF Impact Longitudinal Tau and Cognition in Preclinical Alzheimer's Disease
Yang HS, Yau WW, Carlyle BC, Trombetta BA, Zhang C, Shirzadi Z, Schultz AP, Pruzin JJ, Fitzpatrick CD, Kirn DR, Rabin JS, Buckley RF, Hohman TJ, Rentz DM, Tanzi RE, Johnson KA, Sperling RA, Arnold SE, Chhatwal JP
February 2024 | Journal article | Brain | Read
Data-independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis
Dellar ER, Vendrell I, Talbot K, Kessler BM, Fischer R, Turner MR, Thompson AG
February 2024 | Journal article | Journal of Neurochemistry | Read
Cryo-EM of Soft-landed β-galactosidase: Gas-phase and Native Structures are Remarkably Similar
Esser TK, Böhning J, Önür A, Chinthapalli DK, Eriksson L, Grabarics M, Fremdling P, Konijnenberg A, Makarov A, Botman A, Peter C, Benesch JLP, Robinson CV, Gault J, Baker L, Bharat TAM, Rauschenbach S
February 2024 | Journal article | Science Advances | Read
Single-cell Spatial Transcriptomic and Translatomic Profiling of Dopaminergic Neurons in Health, Aging, and Disease
Kilfeather P, Khoo JH, Wagner K, Liang H, Caiazza MC, An Y, Zhang X, Chen X, Connor-Robson N, Shang Z, Wade-Martins R
February 2024 | Journal article | Cell Reports | Read
A New Architecture for DNA-Templated Synthesis in Which Abasic Sites Protect Reactants from Degradation
Frommer J, Oppenheimer R, Allott BM, Núñez-Pertíñez S, Wilks TR, Cox LR, Bath J, O'Reilly RK, Turberfield AJ
February 2024 | Journal article | Angewandte Chemie | Read
Mechanisms of Aquaporin-4 Vesicular Trafficking in Mammalian Cells
Markou A, Kitchen P, Aldabbagh A, Repici M, Salman MM, Bill RM, Balklava Z
February 2024 | Journal article | Journal of Neurochemistry | Read
Constitutive Activation Mechanism of a Class C GPCR
Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y
February 2024 | Journal article | Nature Structural & Molecular Biology | Read
Repurposing Rapid Diagnostic Tests to Detect Falsified Vaccines in Supply Chains
Bharucha T, Gangadharan B, Clarke R, Fernandez LG, Arman BY, Walsby-Tickle J, Deats M, Mosca S, Lin Q, Stokes R, Dunachie S, Merchant HA, Dubot-Pérès A, Caillet C, McCullagh J, Matousek P, Zitzmann N, Newton PN
February 2024 | Journal article | Science Direct | Read
Magnetically Driven Formation of 3D Freestanding Soft Bioscaffolds
Xie R, Cao Y, Sun R, Wang R, Morgan A, Kim J, Callens SJP, Xie K, Zou J, Lin J, Zhou K, Lu X, Stevens MM
February 2024 | Journal article | Science Advances | Read
Tau Depletion in Human Neurons Mitigates Aβ-driven Toxicity
Ng B, Vowles J, Bertherat F, Abey A, Kilfeather P, Beccano-Kelly D, Stefana MI, O'Brien DP, Bengoa-Vergniory N, Carling PJ, Todd JA, Caffrey TM, Connor-Robson N, Cowley SA, Wade-Martins R
February 2024 | Journal article | Molecular Psychiatry | Read
Neuro-immune Interactions in Health and Disease: Insights from FENS-Hertie 2022 Winter School
Binder LB, Rosa PB, de Sousa BM, Chagas LS, Dubljević O, Martineau FS, Mottarlini F, Castany S, Morton L, Krstanović F, Tassinari ID, Choconta JL, Pereira-Santos AR, Weinhard L, Pallegar PN, Vahsen BF, Lepiarz-Raba I, Compagnion AC, Lorente-Picón M
February 2024 | Journal article | European Journal of Neuroscience | Read
Measuring Protein-Protein Interactions and Quantifying Their Dissociation Constants with Mass Photometry
Kofinova Z, Karunanithy G, Ferreira AS, Struwe WB
January 2024 | Journal article | Current Protocols | Read
PvDBPII Elicits Multiple Antibody-mediated Mechanisms that Reduce Growth in a Plasmodium Vivax Challenge Trial
Martinez FJ, White M, Guillotte-Blisnick M, Huon C, Boucharlat A, Agou F, England P, Popovici J, Hou MM, Silk SE, Barrett JR, Nielsen CM, Reimer JM, Mukherjee P, Chauhan VS, Minassian AM, Draper SJ, Chitnis CE
January 2024 | Journal article | NPJ Vaccines | Read
From Structural Polymorphism to Structural Metamorphosis of the Coat Protein of Flexuous Filamentous Potato Virus Y
Kavčič L, Kežar A, Koritnik N, Žnidarič MT, Klobučar T, Vičič Ž, Merzel F, Holden E, Benesch JLP, Podobnik M
January 2024 | Journal article | Communications Chemistry | Read
Characterization of Membrane Protein Interactions by Peptidisc-mediated Mass Photometry
Young JW, Pfitzner E, van Wee R, Kirschbaum C, Kukura P, Robinson CV
January 2024 | Journal article | iScience | Read
Enhanced Antimalarial and Antisequestration Activity of Methoxybenzenesulfonate-Modified Biopolymers and Nanoparticles for Tackling Severe Malaria
Najer A, Kim J, Saunders C, Che J, Baum J, Stevens MM
January 2024 | Journal article | ACS Infectious Diseases | Read
4D Multi-Material Printing of Soft Actuators with Spatial and Temporal Control
Zhou K, Sun R, Wojciechowski JP, Wang R, Yeow J, Zuo Y, Song X, Wang C, Shao Y, Stevens MM
January 2024 | Journal article | Advanced Materials | Read
IL-33-binding HpARI Family Homologues with Divergent Effects in Suppressing or Enhancing Type 2 Immune Responses
Colomb F, Ogunkanbi A, Jamwal A, Dong B, Maizels RM, Finney CAM, Wasmuth JD, Higgins MK, McSorley HJ
January 2024 | Journal article | Infection and Immunity | Read
Regulation of Inositol 5-phosphatase Activity by the C2 Domain of SHIP1 and SHIP2
Bradshaw WJ, Kennedy EC, Moreira T, Smith LA, Chalk R, Katis VL, Benesch JLP, Brennan PE, Murphy EJ, Gileadi O
January 2024 | Journal article | Structure | Read
Data-independent Acquisition Proteomics of Cerebrospinal Fluid Implicates Endoplasmic Reticulum and Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis.
Dellar ER, Vendrell I, Talbot K, Kessler BM, Fischer R, Turner MR, Thompson AG
December 2023 | Journal article | Journal of Neurochemistry | Read
Mass Spectrometry in Cerebrospinal Fluid Uncovers Association of Glycolysis Biomarkers with Alzheimer's Disease in a Large Clinical Sample.
de Geus MB, Leslie SN, Lam T, Wang W, Roux-Dalvai F, Droit A, Kivisakk P, Nairn AC, Arnold SE, Carlyle BC
December 2023 | Journal article | Scientific Reports | Read
Mutant GGGGCC RNA Prevents YY1 from Binding to Fuzzy Promoter which Stimulates Wnt/β-catenin Pathway in C9ALS/FTD.
Chen ZS, Ou M, Taylor S, Dafinca R, Peng SI, Talbot K, Chan HYE
December 2023 | Journal article | Nature Communications | Read
Mechanisms of aquaporin-4 Vesicular Trafficking in Mammalian Cells.
Markou A, Kitchen P, Aldabbagh A, Repici M, Salman MM, Bill RM, Balklava Z
December 2023 | Journal article | Journal of Neurochemistry | Read
Correction: Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-deficient Neurons.
Hasan S, Fernandopulle MS, Humble SW, Frankenfield AM, Li H, Prestil R, Johnson KR, Ryan BJ, Wade-Martins R, Ward ME, Hao L
December 2023 | Journal article | Molecular Neurodegeneration | Read
The PfRCR Complex Bridges Malaria Parasite and Erythrocyte During Invasion.
Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK
December 2023 | Journal article | Nature | Read
Multilayer DNA Origami with Terminal Interfaces That Are Flat and Wide-Area.
Kilwing L, Lill P, Nathwani B, Guerra R, Benson E, Liedl T, Shih WM
December 2023 | Journal article | ACS Nano | Read
Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease.
Yan S, Jiang C, Janzen A, Barber TR, Seger A, Sommerauer M, Davis JJ, Marek K, Hu MT, Oertel WH, Tofaris GK
December 2023 | Journal article | JAMA Neurology | Read
Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-deficient Neurons.
Hasan S, Fernandopulle MS, Humble SW, Frankenfield AM, Li H, Prestil R, Johnson KR, Ryan BJ, Wade-Martins R, Ward ME, Hao L
November 2023 | Journal article | Molecular Neurodegeneration | Read
Aberrant Topologies of Bacterial Membrane Proteins Revealed by High Sensitivity Fluorescence Labelling.
Hickman SJ, Miller HL, Bukys A, Kapanidis AN, Berks BC
November 2023 | Journal article | Journal of Molecular Biology | Read
Molecular Basis for Selective Uptake and Elimination of Organic Anions in the Kidney by OAT1.
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
November 2023 | Journal article | Nature Structural & Molecular Biology | Read
Penguins Snatch Seconds-long Microsleeps.
Harding CD, Vyazovskiy VV
November 2023 | Journal article | Science | Read
Deep Learning and Single-cell Phenotyping for Rapid Antimicrobial Susceptibility Detection in Escherichia coli.
Zagajewski A, Turner P, Feehily C, El Sayyed H, Andersson M, Barrett L, Oakley S, Stracy M, Crook D, Nellåker C, Stoesser N, Kapanidis AN
November 2023 | Journal article | Communications Biology | Read
Methodological Considerations in Neuronal Extracellular Vesicle Isolation for α-synuclein Biomarkers.
Yan S, Jiang C, Davis JJ, Tofaris GK
November 2023 | Journal article | Brain | Read
Brain Stimulation Techniques as Novel Treatment Options for Insomnia: A Systematic Review.
Krone LB, Fehér KD, Rivero T, Omlin X
November 2023 | Journal article | Journal of Sleep Research | Read
Trypanosomes and Complement: More Than One Way to Die?
Cook AD, Carrington M, Higgins MK
November 2023 | Journal article | Trends in Parasitology | Read
Biocatalytic Reductive Amination as a Route to Isotopically Labelled Amino Acids Suitable for Analysis of Large Proteins by NMR.
Rowbotham JS, Nicholson JH, Ramirez MA, Urata K, Todd PMT, Karunanithy G, Lauterbach L, Reeve HA, Baldwin AJ, Vincent KA
November 2023 | Journal article | Chemical Science | Read
Innovative Method for Rapid Detection of Falsified COVID-19 Vaccines through Unopened Vials Using Handheld Spatially Offset Raman Spectroscopy (SORS).
Mosca S, Lin Q, Stokes R, Bharucha T, Gangadharan B, Clarke R, Fernandez LG, Deats M, Walsby-Tickle J, Arman BY, Chunekar SR, Patil KD, Gairola S, Van Assche K, Dunachie S, Merchant HA, Kuwana R, Maes A, McCullagh J, Caillet C, Zitzmann N, Newton PN, Matousek P
October 2023 | Journal article | Vaccine | Read
Erythrocyte Invasion-neutralising Antibodies Prevent Plasmodium Falciparum RH5 from Binding to Basigin-containing Membrane Protein Complexes.
Jamwal A, Constantin CF, Hirschi S, Henrich S, Bildl W, Fakler B, Draper SJ, Schulte U, Higgins MK
October 2023 | Journal article | Elife | Read
A Quinolin-8-ol Sub-millimolar Inhibitor of UGGT, the ER Glycoprotein Folding Quality Control Checkpoint.
Guay KP, Ibba R, Kiappes JL, Vasiljević S, Bonì F, De Benedictis M, Zeni I, Le Cornu JD, Hensen M, Chandran AV, Kantsadi AL, Caputo AT, Blanco Capurro JI, Bayo Y, Hill JC, Hudson K, Lia A, Brun J, Withers SG, Martí M, Biasini E, Santino A, De Rosa M, Milani M, Modenutti CP, Hebert DN, Zitzmann N, Roversi P
October 2023 | Journal article | iScience | Read
Structural Basis for Triacylglyceride Extraction from Mycobacterial Inner Membrane by MFS Transporter Rv1410.
Remm S, De Vecchis D, Schöppe J, Hutter CAJ, Gonda I, Hohl M, Newstead S, Schäfer LV, Seeger MA
October 2023 | Journal article | Nature Communications | Read
Single Particle Chemical Characterisation of Nanoformulations for Cargo Delivery.
Saunders C, de Villiers CA, Stevens MM
October 2023 | Journal article | The AAPS Journal | Read
Patient-derived iPSC Models of Friedreich Ataxia: A New Frontier for Understanding Disease Mechanisms and Therapeutic Application.
Maheshwari S, Vilema-Enríquez G, Wade-Martins R
September 2023 | Journal article | Translational Neurodegeneration | Read
A New Twist on PIFE: Photoisomerisation-related Fluorescence Enhancement.
Ploetz E, Ambrose B, Barth A, Börner R, Erichson F, Kapanidis AN, Kim HD, Levitus M, Lohman TM, Mazumder A, Rueda D, Steffen FD, Cordes T, Magennis S, Lerner E
September 2023 | Journal article | Methods and Applications in Fluorescence | Read
Trypanosomes and Complement: More than One Way to Die?
Cook AD, Carrington M, Higgins MK
September 2023 | Journal article | Trends in Parasitology | Read
Astrocytes in Functional Recovery Following Central Nervous System Injuries.
Alhadidi QM, Bahader GA, Arvola O, Kitchen P, Shah ZA, Salman MM
September 2023 | Journal article | The Journal of Physiology | Read
PRMT Inhibitor Promotes SMN2 Exon 7 Inclusion and Synergizes with Nusinersen to Rescue SMA Mice.
Kordala AJ, Stoodley J, Ahlskog N, Hanifi M, Garcia Guerra A, Bhomra A, Lim WF, Murray LM, Talbot K, Hammond SM, Wood MJ, Rinaldi C
September 2023 | Journal article | EMBO Molecular Medicine | Read
C9orf72-ALS Human iPSC Microglia are Pro-inflammatory and Toxic to Co-cultured Motor Neurons via MMP9.
Vahsen BF, Nalluru S, Morgan GR, Farrimond L, Carroll E, Xu Y, Cramb KML, Amein B, Scaber J, Katsikoudi A, Candalija A, Carcolé M, Dafinca R, Isaacs AM, Wade-Martins R, Gray E, Turner MR, Cowley SA, Talbot K
September 2023 | Journal article | Nature Communications | Read
Mitochondrial Dysfunction and Mitophagy Defects in LRRK2-R1441C Parkinson's Disease Models.
Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Malpartida AB, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R
September 2023 | Journal article | Human Molecular Genetics | Read
Infrared Multiphoton Dissociation Enables Top-Down Characterization of Membrane Protein Complexes and G Protein-Coupled Receptors.
Lutomski CA, El-Baba TJ, Hinkle JD, Liko I, Bennett JL, Kalmankar NV, Dolan A, Kirschbaum C, Greis K, Urner LH, Kapoor P, Yen HY, Pagel K, Mullen C, Syka JEP, Robinson CV
September 2023 | Journal article | Angewandte Chemie | Read
Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson's Disease Patients Carrying the Heterozygous Mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1.
Chemla A, Arena G, Onal G, Walter J, Berenguer-Escuder C, Grossmann D, Grünewald A, Schwamborn JC, Krüger R
September 2023 | Journal article | Stem Cell Research | Read
The Dual Action of Human Antibodies Specific to Plasmodium Falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites.
Weiss GE, Ragotte RJ, Quinkert D, Lias AM, Dans MG, Boulet C, Looker O, Ventura OD, Williams BG, Crabb BS, Draper SJ, Gilson PR
September 2023 | Journal article | PLoS Pathogens | Read
Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels.
Cole BA, Becker EBE
September 2023 | Journal article | Cells | Read
Structural Characterization of Human Urea Transporters UT-A and UT-B and Their Inhibition.
Chi G, Dietz L, Tang H, Snee M, Scacioc A, Wang D, Mckinley G, Mukhopadhyay SMM, Pike ACW, Chalk R, Burgess-Brown NA, Timmermans JP, van Putte W, Robinson CV, Dürr KL
September 2023 | Journal article | Science Advances | Read
Continuous Home Cage Monitoring of Activity and Sleep in Mice During Repeated Paroxetine Treatment and Discontinuation.
Collins HM, Pinacho R, Tam SKE, Sharp T, Bannerman DM, Peirson SN
August 2023 | Journal article | Psychopharmacology | Read
Correction to "Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease".
Quinn JP, Ethier EC, Novielli A, Malone A, Ramirez CE, Salloum L, Trombetta BA, Kivisäkk P, Bremang M, Selzer S, Fournier M, Das S, Xing Y, Arnold SE, Carlyle BC
August 2023 | Journal article | Journal of the American Society for Mass Spectrometry | Read
Transcending Markov: Non-Markovian Rate Processes of Thermosensitive TRP Ion Channels.
Ben-Abu Y, Tucker SJ, Contera S
August 2023 | Journal article | Royal Society Open Sci | Read
Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.
Burnap SA, Ortega-Prieto AM, Jimenez-Guardeño JM, Ali H, Takov K, Fish M, Shankar-Hari M, Giacca M, Malim MH, Mayr M
August 2023 | Journal article | Molecular & Cellular Proteomics | Read
Advantages of Routine Next-generation Sequencing Over Standard Genetic Testing in the Amyotrophic Lateral Sclerosis Clinic.
Scaber J, Thompson AG, Farrimond L, Feneberg E, Proudfoot M, Ossher L, Turner MR, Talbot K
August 2023 | Journal article | European Journal of Neuralogy | Read
RNA Polymerase Redistribution Supports Growth in E. coli Strains with a Minimal Number of rRNA Operons.
Fan J, El Sayyed H, Pambos OJ, Stracy M, Kyropoulos J, Kapanidis AN
August 2023 | Journal article | Nucleic Acids Research | Read
A Quantitative Description for Optical Mass Measurement of Single Biomolecules.
Becker J, Peters JS, Crooks I, Helmi S, Synakewicz M, Schuler B, Kukura P
August 2023 | Journal article | ACS Photonics | Read
Superior Antibody Immunogenicity of a Viral-vectored RH5 Blood-stage Malaria Vaccine in Tanzanian Infants as Compared to Adults.
Silk SE, Kalinga WF, Mtaka IM, Lilolime NS, Mpina M, Milando F, Ahmed S, Diouf A, Mkwepu F, Simon B, Athumani T, Rashid M, Mohammed L, Lweno O, Ali AM, Nyaulingo G, Mwalimu B, Mswata S, Mwamlima TG, Barrett JR, Wang LT, Themistocleous Y, King LDW, Hodgson SH, Payne RO, Nielsen CM, Lawrie AM, Nugent FL, Cho JS, Long CA, Miura K, Draper SJ, Minassian AM, Olotu AI
August 2023 | Journal article | Clinical Advances | Read
The Solute Carrier SPNS2 Recruits PI(4,5)P2 to Synergistically Regulate Transport of Sphingosine-1-Phosphate.
Tang H, Li H, Prakaash D, Pedebos C, Qiu X, Sauer DB, Khalid S, Duerr K, Robinson CV
August 2023 | Journal article | Molecular Science | Read
Structural Basis of Telomeric Nucleosome Recognition by Shelterin Factor TRF1.
Hu H, van Roon AM, Ghanim GE, Ahsan B, Oluwole AO, Peak-Chew SY, Robinson CV, Nguyen THD
August 2023 | Journal article | Science Advances | Read
ProSight Native: Defining Protein Complex Composition from Native Top-Down Mass Spectrometry Data.
Durbin KR, Robey MT, Voong LN, Fellers RT, Lutomski CA, El-Baba TJ, Robinson CV, Kelleher NL
August 2023 | Journal article | Journal of Proteome Research | Read
A Review of Broadly Protective Monoclonal Antibodies to Treat Ebola Virus Disease.
Rijal P, Donnellan FR
August 2023 | Journal article | Current Opinion in Virology | Read
Impaired Dopamine Release in Parkinson's Disease.
Cramb KML, Beccano-Kelly D, Cragg SJ, Wade-Martins R
August 2023 | Journal article | Brain | Read
Visualization of Direct and Diffusion-assisted RAD51 Nucleation by Full-length Human BRCA2 Protein.
Belan O, Greenhough L, Kuhlen L, Anand R, Kaczmarczyk A, Gruszka DT, Yardimci H, Zhang X, Rueda DS, West SC, Boulton SJ
July 2023 | Journal article | Molecular Cell | Read
The Solute Carrier SPNS2 Recruits PI(4,5)P2 to Synergistically Regulate Transport of Sphingosine-1-Phosphate.
Tang H, Li H, Prakaash D, Pedebos C, Qiu X, Sauer DB, Khalid S, Duerr K, Robinson CV
July 2023 | Journal article | Molecular Cell | Read
Molecular Basis for Selective Uptake and Elimination of Organic Anions in the Kidney by OAT1
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
July 2023 | Journal article | Nature Structural & Molecular Biology | Read
Correction: Limitations of Non-polarizable Force Fields in Describing Anion Binding Poses in Non-polar Synthetic Hosts
Seiferth D, Tucker SJ, Biggin PC
July 2023 | Journal article | Physical Chemistry Chemical Physics | Read
The Beauty and Complexity of the Small Heat Shock Proteins: A Report on the Proceedings of the Fourth Workshop on Small Heat Shock Proteins.
Ecroyd H, Bartelt-Kirbach B, Ben-Zvi A, Bonavita R, Bushman Y, Casarotto E, Cecconi C, Lau WCY, Hibshman JD, Joosten J, Kimonis V, Klevit R, Liberek K, McMenimen KA, Miwa T, Mogk A, Montepietra D, Peters C, Rocchetti MT, Saman D, Sisto A, Secco V, Strauch A, Taguchi H, Tanguay M, Tedesco B, Toth ME, Wang Z, Benesch JLP, Carra S
July 2023 | Journal article | Cell Stress and Chaperones | Read
Vaccination with Plasmodium vivax Duffy-binding Protein Inhibits Parasite Growth During Controlled Human Malaria Infection.
Hou MM, Barrett JR, Themistocleous Y, Rawlinson TA, Diouf A, Martinez FJ, Nielsen CM, Lias AM, King LDW, Edwards NJ, Greenwood NM, Kingham L, Poulton ID, Khozoee B, Goh C, Hodgson SH, Mac Lochlainn DJ, Salkeld J, Guillotte-Blisnick M, Huon C, Mohring F, Reimer JM, Chauhan VS, Mukherjee P, Biswas S, Taylor IJ, Lawrie AM, Cho JS, Nugent FL, Long CA, Moon RW, Miura K, Silk SE, Chitnis CE, Minassian AM, Draper SJ
July 2023 | Journal article | Science Translational Medicine | Read
ProSight Native: Defining Protein Complex Composition from Native Top-Down Mass Spectrometry Data.
Durbin KR, Robey MT, Voong LN, Fellers RT, Lutomski CA, El-Baba TJ, Robinson CV, Kelleher NL
July 2023 | Journal article | Journal of Proteome Research | Read
Dimerization of European Robin Cryptochrome 4a.
Hanić M, Antill LM, Gehrckens AS, Schmidt J, Görtemaker K, Bartölke R, El-Baba TJ, Xu J, Koch KW, Mouritsen H, Benesch JLP, Hore PJ, Solov'yov IA
July 2023 | Journal article | The Journal of Physical Chemistry | Read
Calcium Dysregulation Combined with Mitochondrial Failure and Electrophysiological Maturity Converge in Parkinson's iPSC-dopamine Neurons.
Beccano-Kelly DA, Cherubini M, Mousba Y, Cramb KML, Giussani S, Caiazza MC, Rai P, Vingill S, Bengoa-Vergniory N, Ng B, Corda G, Banerjee A, Vowles J, Cowley S, Wade-Martins R
July 2023 | Journal article | iScience | Read
Recent Advances in Membrane Mimetics for Membrane Protein Research.
Young JW
Jun 2023 | Journal article | Biochemical Society Transactions | Read
Bleaching-resistant, Near-continuous Single-molecule Fluorescence and FRET Based on Fluorogenic and Transient DNA Binding.
Kümmerlin M, Mazumder A, Kapanidis AN
Jun 2023 | Journal article | ChemPhysChem | Read
Monitoring α-synuclein Ubiquitination Dynamics Reveals Key Endosomal Effectors Mediating its Trafficking and Degradation.
Zenko D, Marsh J, Castle AR, Lewin R, Fischer R, Tofaris GK
Jun 2023 | Journal article | Science Advances | Read
Mitochondrial Dysfunction and Mitophagy Defects in LRRK2-R1441C Parkinson's Disease Models.
Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Belen Malpartida A, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R
Jun 2023 | Journal article | Human Molecular Genetics | Read
Effect of Temperature and Nucleotide on the Binding of BiP Chaperone to a Protein Substrate.
Rivera M, Burgos-Bravo F, Engelberger F, Asor R, Lagos-Espinoza MIA, Figueroa M, Kukura P, Ramírez-Sarmiento CA, Baez M, Smith SB, Wilson CAM
Jun 2023 | Journal article | Protein Science | Read
High-throughput Super-resolution Analysis of Influenza Virus Pleomorphism Reveals Insights into Viral Spatial Organization.
McMahon A, Andrews R, Groves D, Ghani SV, Cordes T, Kapanidis AN, Robb NC
Jun 2023 | Journal article | PLoS Pathogens | Read
Cross-linking Mass Spectrometry Uncovers Interactions Between High-density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.
Burnap SA, Ortega-Prieto AM, Jimenez-Guardeño JM, Ali H, Takov K, Fish M, Shankar-Hari M, Giacca M, Malim MH, Mayr M
Jun 2023 | Journal article | Molecular & Cellular Proteomics | Read
Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson's Disease Patients Carrying the Heterozygous Mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1.
Chemla A, Arena G, Onal G, Walter J, Berenguer-Escuder C, Grossmann D, Grünewald A, Schwamborn JC, Krüger R
Jun 2023 | Journal article | Stem Cell Research | Read
RNA polymerase Redistribution Supports Growth in E. coli Strains with a Minimal Number of rRNA Operons.
Fan J, El Sayyed H, Pambos OJ, Stracy M, Kyropoulos J, Kapanidis AN
Jun 2023 | Journal article | Nucleic Acids Research | Read
Limitations of Non-polarizable Force Fields in Describing Anion Binding Poses in Non-polar Synthetic Hosts.
Seiferth D, Tucker SJ, Biggin PC
Jun 2023 | Journal article | Physical Chemistry Chemical Physics | Read
Rationalizing the Optimization of Detergents for Membrane Protein Purification.
Urner LH, Junge F, Fiorentino F, El-Baba TJ, Shutin D, Nölte G, Haag R, Robinson CV
May 2023 | Journal article | Chemistry Europe | Read
Methodological Considerations in Neuronal Extracellular Vesicle Isolation for α-synuclein Biomarkers.
Yan S, Jiang C, Davis JJ, Tofaris GK
May 2023 | Journal article | Brain | Read
Brain Stimulation Techniques as Novel Treatment Options for Insomnia: A Systematic Review.
Krone LB, Fehér KD, Rivero T, Omlin X
May 2023 | Journal article | Journal of Sleep Research | Read
Single-molecule FRET for Virology: 20 Years of Insight into Protein Structure and Dynamics.
Groves D, Hepp C, Kapanidis AN, Robb NC
May 2023 | Journal article | Quarterly Reviews of Biophysics | Read
Deep Proteomics Network and Machine Learning Analysis of Human Cerebrospinal Fluid in Japanese Encephalitis Virus Infection.
Bharucha T, Gangadharan B, Kumar A, Myall AC, Ayhan N, Pastorino B, Chanthongthip A, Vongsouvath M, Mayxay M, Sengvilaipaseuth O, Phonemixay O, Rattanavong S, O'Brien DP, Vendrell I, Fischer R, Kessler B, Turtle L, de Lamballerie X, Dubot-Pérès A, Newton PN, Zitzmann N, SEAe Consortium
May 2023 | Journal article | Journal of Proteome Research | Read
α-Synuclein Fibril and Synaptic Vesicle Interactions Lead to Vesicle Destruction and Increased Lipid-Associated Fibril Uptake into iPSC-derived Neurons.
Stephens AD, Villegas AF, Chung CW, Vanderpoorten O, Pinotsi D, Mela I, Ward E, McCoy TM, Cubitt R, Routh AF, Kaminski CF, Kaminski Schierle GS
May 2023 | Journal article | Communications Biology | Read
A Modular RNA Delivery System Comprising Spherical Nucleic Acids Built on Endosome-escaping Polymeric Nanoparticles.
Garcia-Guerra A, Ellerington R, Gaitzsch J, Bath J, Kye M, Varela MA, Battaglia G, Wood MJA, Manzano R, Rinaldi C, Turberfield AJ.
May 2023 | Journal article | Nanoscale Advances | Read
Alternating Magnetic Field-Promoted Nanoparticle Mixing: The On-Chip Immunocapture of Serum Neuronal Exosomes for Parkinson's Disease Diagnostics.
Sharafeldin M, Yan S, Jiang C, Tofaris GK, Davis JJ
May 2023 | Journal article | Analytical Chemistry | Read
Advantages of Routine Next Generation Sequencing Over Standard Genetic Testing in the ALS Clinic.
Scaber J, Thompson AG, Farrimond L, Feneberg E, Proudfoot M, Ossher L, Turner MR, Talbot K
May 2023 | Journal article | Europen Journal of Neurology | Read
G Protein-Coupled Receptor Pharmacology-Insights from Mass Spectrometry
Yen HY, Jazayeri A, Robinson CV
May 2023 | Journal article | Pharmacological Reviews | Read
Temporal Transcriptional Control of Neural Induction in Human Induced Pluripotent Stem Cells
Gupta S, Polit LD, Fitzgerald M, Rowland HA, Murali D, Buckley NJ, Subramaniam S
May 2023 | Journal article | Frontiers in Molecular Neuroscience | Read
Reconfigurable Self-Assembled DNA Devices
Benson E, Bath J
April 2023 | Journal article | Science Robotics | Read
Bleaching-resistant, Near-continuous Single-molecule Fluorescence and FRET Based on Fluorogenic and Transient DNA Binding
Kümmerlin M, Mazumder A, Kapanidis AN
April 2023 | Journal article | Chemphyschem | Read
Reliability and Accuracy of Single-molecule FRET Studies for Characterization of Structural Dynamics and Distances in Proteins
Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T
April 2023 | Journal article | Nature Methods | Read
Shapeshifting Bullvalene-linked Vancomycin Dimers as Effective Antibiotics Against Multidrug-resistant Gram-positive Bacteria
Ottonello A, Wyllie JA, Yahiaoui O, Sun S, Koelln RA, Homer JA, Johnson RM, Murray E, Williams P, Bolla JR, Robinson CV, Fallon T, Soares da Costa TP, Moses JE
April 2023 | Journal article | PNAS | Read
Fortuitously Compatible Protein Surfaces Primed Allosteric Control in Cyanobacterial Photoprotection
Steube N, Moldenhauer M, Weiland P, Saman D, Kilb A, Rojas AAR, Garg SG, Schindler D, Graumann PL, Benesch JLP, Bange G, Friedrich T, Hochberg GKA
April 2023 | Journal article | Nature Ecology & Evolution | Read
Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease
Quinn JP, Ethier EC, Novielli A, Malone A, Ramirez CE, Salloum L, Trombetta BA, Kivisäkk P, Bremang M, Selzer S, Fournier M, Das S, Xing Y, Arnold SE, Carlyle BC
March 2023 | Journal article | Journal of the American Society for Mass Spectrometry | Read
An in-solution Snapshot of SARS-COV-2 Main Protease Maturation Process and Inhibition
Noske GD, Song Y, Fernandes RS, Chalk R, Elmassoudi H, Koekemoer L, Owen CD, El-Baba TJ, Robinson CV, COVID Moonshot Consortium, Oliva G, Godoy AS
March 2023 | Journal article | Nature Communications | Read
Influence of Electronic Polarization on the Binding of Anions to a Chloride-pumping Rhodopsin
Phan LX, Chamorro VC, Martinez-Seara H, Crain J, Sansom MSP, Tucker SJ
March 2023 | Journal article | Biophysical Journal | Read
A Special Issue of Essays in Biochemistry on Structural Mass Spectrometry
Britt HM, Beveridge R , Calabrese AN
March 2023 | Journal article | Essays Biochem | Read
Uncovering the Role of N-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry
El-Baba TJ, Lutomski CA, Burnap SA, Bolla JR, Baker LA, Baldwin AJ, Struwe WB, Robinson CV
March 2023 | Journal article | JACS | Read
Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays
Tyrrell BE, Kumar A, Gangadharan B, Alonzi D, Brun J, Hill M, Bharucha T, Bosworth A, Graham V, Dowall S, Miller JL, Zitzmann N
March 2023 | Journal article | Pathogens | Read
A Quantitative Description for Optical Mass Measurement of Single Biomolecules
Becker J, Peters JS, Crooks I, Helmi S, Synakewicz M, Schuler B, Kukura P
March 2023 | Journal article | bioRxiv | Read
Post-translational Proteomics Platform Identifies Neurite Outgrowth Impairments in Parkinson's Disease GBA-N370S Dopamine Neurons
Bogetofte H, Ryan BJ, Jensen P, Schmidt SI, Vergoossen DLE, Barnkob MB, Kiani LN, Chughtai U, Heon-Roberts R, Caiazza MC, McGuinness W, Márquez-Gómez R, Vowles J, Bunn FS, Brandes J, Kilfeather P, Connor JP, Fernandes HJR, Caffrey TM, Meyer M, Cowley SA, Larsen MR, Wade-Martins R
March 2023 | Journal article | Cell Reports | Read
In Conversation with Carol Robinson
Dhillon P, Robinson C.
March 2023 | Journal article | Febs | Read
Effects of Clozapine-N-oxide and Compound 21 on Sleep in Laboratory Mice
Traut J, Mengual JP, Meijer EJ, McKillop LE, Alfonsa H, Hoerder-Suabedissen A, Song SH, Fehér KD, Riemann D, Molnar Z, Akerman CJ, Vyazovskiy VV, Krone LB
March 2023 | Journal article | eLife | Read
Rationalizing the Optimization of Detergents for Membrane Protein Purification
Urner LH, Junge F, Fiorentino F, El-Baba TJ, Shutin D, Nölte G, Haag R, Robinson CV
March 2023 | Journal article | Chemistry | Read
Impaired Dopamine Release in Parkinson’s Disease
Cramb KML, Beccano-Kelly D, Cragg SJ, Wade-Martins R
March 2023 | Journal article | Brain | Read
Mass Spectrometry of Intact Membrane Proteins: Shifting Towards a More Native-like Context
Oluwole A, Shutin D, Bolla JR
February 2023 | Journal article | Essays in Biochemistry | Read
Posttranslational, Site-directed Photochemical Fluorine Editing of Protein Sidechains to Probe Residue Oxidation State via 19F-nuclear Magnetic Resonance
Isenegger PG, Josephson B, Gaunt B, Davy MJ, Gouverneur V, Baldwin AJ, Davis BG
February 2023 | Journal article | Nature Protocols | Read
Detection of Neuronal OFF Periods as Low Amplitude Neural Activity Segments
Harding CD, Guillaumin MCC, Krone LB, Kahn MC, Blanco-Duque C, Mikutta C, Vyazovskiy VV
February 2023 | Journal article | BMC Neuroscience | Read
HS 3D-SeboSkin Model Enables the Preclinical Exploration of Therapeutic Candidates for Hidradenitis Suppurativa/Acne Inversa
Cramb KML, Beccano-Kelly D, Cragg SJ, Wade-Martins R
February 2023 | Journal article | Pharmaceutics | Read
Functional Integrity of Visual Coding Following Advanced Photoreceptor Degeneration
Rodgers J, Hughes S, Lindner M, Allen AE, Ebrahimi AS, Storchi R, Peirson SN, Lucas RJ, Hankins MW
January 2023 | Journal article | Current Biology | Read
Efficiently Computing the Uhlmann Fidelity for Density Matrices
Baldwin AJ and Jones JA
January 2023 | Journal article | Physical Review A | Read
Unconventional Secretion of alpha-synuclein Mediated by Palmitoylated DNAJC5 Oligomers
Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R
January 2023 | Journal article | eLife | Read
A Dual Detergent Strategy to Capture a Bacterial Outer Membrane Proteome in Peptidiscs for Characterization by Mass Spectrometry and Binding Assays
Young JW, Zhao ZY, Wason IS, van Hoa FD
December 2022 | Journal article | Journal of Proteome Research | Read
“Paradoxical wakefulness” Induced by Psychedelic 5-methoxy-N, N-dimethyltryptamine in Mice
JB Bréant BJB, Mengual JP, Bannerman DM, Sharp T, Vyazovskiy VV
December 2022 | Journal article | Progress in Brain Research | Read
Coalescing Aptamers and Liquid-Crystals for Sensing Applications
Kulabhusana PK, Ray R, Ramachandra SG, Srinivasulu M, Hariharan A, Balaji K, Mani NK
December 2022 | Journal article | Microchemical Journal | Read
Neurons Derived from Individual Early Alzheimer's Disease Patients Reflect Their Clinical Vulnerability
Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R
November 2022 | Journal article | Brain Communications | Read
Single-Molecule Trapping and Measurement in a Nanostructured Lipid Bilayer System
Bespalova M, Öz R, Westerlund F, Krishnan M
November 2022 | Journal article | Langmuir | Read
Glycosylated Clusterin Species Facilitate Aβ Toxicity in Human Neurons
Foster EM, Fernandes M, Dangla-Valls A, Hublitz P, Pangalos M, Lovestone S, Ribe EM, Buckley NJ
November 2022 | Journal article | Scientific Reports | Read
Expansion and Neofunctionalization of Actinoporin-like Genes in Mediterranean Mussel (Mytilus galloprovincialis)
Koritnik N, Gerdol M, Šolinc G, Švigelj T, Caserman S, Merzel F, Holden E, Benesch JLP, Trenti F, Guella G, Pallavicini A, Modica MV, Podobnik M, Anderluh G
November 2022 | Journal article | Genome Biology and Evolution | Read
Anionic Lipids Unlock the Gates of Select Ion Channels in the Pacemaker Family
Schmidpeter PAM, Wu D, Rheinberger J, Riegelhaupt PM, Tang H, Robinson CV, Nimigean CM
November 2022 | Journal article | Nature Structural & Molecular Biology | Read
Mass Spectrometry Captures Biased Signalling and Allosteric Modulation of a G-Protein-Coupled Receptor
Yen HY, Liko I, Song W, Kapoor P, Almeida F, Toporowska J, Gherbi K, Hopper JTS, Charlton S, Politis A, Sansom MSP, Jazayeri A, Robinson CV
November 2022 | Journal article | Nature Chemistry | Read
Native Top-Down Mass Spectrometry Reveals a Role for Interfacial Glycans on Therapeutic Cytokine and Hormone Assemblies
Wu D and Robinson CV
November 2022 | Journal article | Angewandte Chemie-International Edition | Read
CryoEM of Endogenous Mammalian V-ATPase Interacting with the TLDc Protein mEAK-7
Tan YZ , Abbas YM, Wu JZ, Wu D, Keon KA, Hesketh GG, Bueler SA, Gingras AC, Robinson CV, Grinstein S, Rubinstein JL
November 2022 | Journal article | Life Science Alliance | Read
Lipids Mediate Supramolecular Outer Membrane Protein Assembly in Bacteria
Webby MN, Oluwole AO, Pedebos C, Inns PG, Olerinyova A, Prakaash D, Housden NG, Benn G, Sun D, Hoogenbook BW, Kukura P, Mohammed S, Robinson CV, Khalid S, Kleanthous C
November 2022 | Journal article | Science Advances | Read
When is a hydrophobic gate not a hydrophobic gate?
Seiferth D, Biggin PC, Tucker SJ
October 2022 | Journal article | Journal of General Physiology | Read
Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models
Ndunge OBA, Kilian N, Salman MM
October 2022 | Journal article | Advanced Science | Read
GPC3-Unc5 Receptor Complex Structure and Role in Cell Migration
Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, Lowe E, Ben Amar D, Zaballa S, Huo J, Pakos I, McCubbin PTN, Comoletti D, Owens RJ, Robinson CV, Castellani V, Del Toro D, Seiradake E
October 2022 | Journal article | Cell | Read
GPR97 Triggers Inflammatory Processes in Human Neutrophils via a Macromolecular Complex Upstream of PAR2 Activation
Chu TY, Zheng-Gérard C, Huang KY, Chang YC, Chen YW, I KY, Lo YL, Chiang NY, Chen HY, Stacey M, Gordon S, Tseng WY, Sun CY, Wu YM, Pan YS, Huang CH, Lin CY, Chen TC, El Omari K, Antonelou M, Henderson SR, Salama A, Seiradake E & Lin HH
October 2022 | Journal article | Nature Communications | Read
Neurons Derived from Individual Early Alzheimer’s Disease Patients Reflect Their Clinical Vulnerability
Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R
October 2022 | Journal article | Brain Communications | Read
Mass Photometry Reveals SARS-CoV-2 Spike Stabilisation to Impede ACE2 Binding Through Altered Conformational Dynamics
Burnap SA, Struwe W
October 2022 | Journal article | Chemical Communications | Read
Gain-of-function Mutations in KCNK3 Cause a Developmental Disorder with Sleep Apnea
Sörmann J, Schewe M, Proks P, Jouen-Tachoire T, Rao S, Riel EB, Agre KE, Begtrup A, Dean J, Descartes M, Fischer J, Gardham A, Lahner C, Mark PR, Muppidi S, Pichurin PN, Porrmann J, Schallner J, Smith K, Straub V, Vasudevan P, Willaert R, Carpenter EP, Rödström KEJ, Hahn MG, Müller T, Baukrowitz T, Hurles ME, Wright CF, Tucker SJ.
October 2022 | Journal article | Nature Genetics | Read
Repressor Element 1-Silencing Transcription Factor Deficiency Yields Profound Hearing Loss Through K(v)7.4 Channel Upsurge in Auditory Neurons and Hair Cells
Zhang H, Li H, Lu M, Wang S, Ma X, Wang F, Liu J, Li X, Yang H, Zhang F, Shen H, Buckley NJ, Gamper N, Yamoah EN, Lv P
September 2022 | Journal article | eLife | Read
Far-Field Electrostatic Signatures of Macromolecular 3D Conformation
Kloes G, Bennett TJD, Chapet-Batlle A, Behjatian A, Turberfield AJ, Krishnan M
September 2022 | Journal article | Nano Letters | Read
Purkinje Cell Patterning—Insights from Single-Cell Sequencing
Apsley EJ, Becker EBE
September 2022 | Journal article | Cells | Read
Structure of the Malaria Vaccine Candidate Pfs48/45 and its Recognition by Transmission Blocking Antibodies
Ko KT, Lennartz F, Mekhaiel D, Guloglu B, Marini A, Deuker DJ, Long CA, Jore MM, Miura K, Biswas S, Higgins MK
September 2022 | Journal article | Nature Communications | Read
Invariant Surface Glycoprotein 65 of Trypanosoma Brucei is a Complement C3 Receptor
Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M
September 2022 | Journal article | Nature Communications | Read
Multiplex Lateral Flow Assay and the Sample Preparation Method for the Simultaneous Detection of Three Marine Toxins
Mills C, Dillon MJ, Kulabhusan PK, Senovilla-Herrero D, Campbell K
September 2022 | Journal article | Environmental Science & Technology | Read
Direct Observation of the Molecular Mechanism Underlying Protein Polymerization
Hundt N, Cole D, Hantke MF, Miller JJ, Struwe WB, Kukura P
August 2022 | Journal article | Science Advances | Read
Structural Basis for Proton Coupled Cystine Transport by Cystinosin
Löbel M, Salphati SP, El Omari K, Wagner A, Tucker SJ, Parker JL, Newstead S
August 2022 | Journal article | Nature Communications | Read
Re-examining Extreme Sleep Duration in Bats: Implications for Sleep Phylogeny, Ecology, and Function
Harding CD, Yovel Y, Peirson SN, Hackett TD, Vyazovskiy VV
August 2022 | Journal article | Sleep | Read
A new class of biological ion-driven rotary molecular motors with 5:2 symmetry
Rieu M, Krutyholowa R, Taylor NMI, Berry RM
August 2022 | Journal article | Frontiers in Microbiology | Read
Invariant Surface Glycoprotein 65 of Trypanosoma Brucei is a Complement C3 Receptor
Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M
August 2022 | Journal article | Nature Communications | Read
Human iPSC Co-culture Model to Investigate the Interaction between Microglia and Motor Neurons
Vahsen BF, Gray E, Candalija A, Cramb KML, Scaber J, Dafinca R, Katsikoudi A, Xu Y, Farrimond L, Wade-Martins R, James WS, Turner MR, Cowley SA, Talbot K
July 2022 | Journal article | Scientific Reports | Read
Pathogen-sugar Interactions Revealed by Universal Saturation Transfer Analysis.
Buchanan CJ, Baldwin A, et al.
July 2022 | Journal article | Science | Read
Influence of Effective Polarization on Ion and Water Interactions within a Biomimetic Nanopore
Phan LX, Lynch CI, Crain J, Sansom MSP, Tucker SJ
June 2022 | Journal article | Biophysical Journal | Read
No Association Between Amygdala Responses to Negative Faces and Depressive Symptoms: Cross-Sectional Data from 28,638 Individuals in the UK Biobank Cohort
Tamm S, Harmer CJ, Schiel J, Holub F, Rutter MK, Spiegelhalder K, Kyle SD
June 2022 | Journal article | The American Journal of Psychiatry | Read
Patched 1 Regulates Smoothened by Controlling Sterol Binding to its Extracellular Cysteine-rich Domain
Kinnebrew M, Woolley RE, Ansell, TB, Byrne, EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey D, Siebold C, Rohatgi R
June 2022 | Journal article | Science Advances | Read
Cryo-EM Structures of Pentameric Autoinducer-2 Exporter from Escherichia Coli Reveal its Transport Mechanism
Khera R, Mehdipour AR, Bolla JR, Kahnt J, Welsch S, Ermler U, Muenke C, Robinson CV, Hummer G, Xie H
June 2022 | Journal article | The EMBO Journal | Read
Characterising Biomolecular Interactions and Dynamics with Mass Photometry.
Asor R and Kukura P
June 2022 | Journal article | Current Opinion in Chemical Biology | Read
Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease.
Carlyle BC, Kitchen RR, Mattingly Z, Celia AM, Trombetta BA, Das S, Hyman BT, Kivisäkk P, Arnold SE
June 2022 | Journal article | Frontiers in Neurology | Read
Evidence‐informed is not enough: digital therapeutics also need to be evidence‐based.
Espie CA, Firth J, Torous J
June 2022 | Journal article | World Psychiatry | Read
Studies on enmetazobactam clarify mechanisms of widely used beta-lactamase inhibitors.
Lang PA, Raj R, Tumber A, Lohans CT, Rabe P, Robinson CV, Brem JU, Schofield CJ
May 2022 | Journal article | Proceedings of the National Academy of Sciences of the United States of America | Read
Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.
Burley S, Beccano-Kelly DA, Talbot K, Llana OC, Wade-Martins R
May 2022 | Journal article | Scientific Reports | Read
Multivalent interactions essential for lentiviral integrase function.
Ballandras-Colas A, Chivukula V, Gruszka DT, Shan ZL, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, Taylor IA, Lyumkis D, Yardimci H, Engelman AN, Cherepanov P
May 2022 | Journal article | Nature Communications | Read
Initiation and progression of alpha-synuclein pathology in Parkinson's disease.
Tofaris GK.
April 2022 | Journal article | Cellular and Molecular Life Sciences | Read
Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients.
Oluwole AO, Corey RA, Brown CM, Hernandez-Rocamora VM, Stansfeld PJ, Vollmer W, Bolla JR, Robinson CV
April 2022 | Journal article | Nature Communications | Read
Capturing a rhodopsin receptor signalling cascade across a native membrane.
Chen SY, Getter T, Salom D, Wu D, Quetschlich D, Chorev DS, Palczewski K, Robinson CV
April 2022 | Journal article | Nature | Read
Template-directed conjugation of heterogeneous oligonucleotides to a homobifunctional molecule for programmable supramolecular assembly.
Helmi S, Turberfield AJ
March 2022 | Journal article | Nanoscale | Read
Re-examining extreme sleep duration in bats: implications for sleep phylogeny, ecology, and function.
Harding CD, Yovel Y, Peirson SN, Hackett TD, Vyazovskiy VV
March 2022 | Journal article | Sleep | Read
Ion and water interactions with a biomimetic nanopore: molecular dynamics with effective polarization
Phan LX, Lynch CI, Crain J, Sansom MSP, Tucker SJ
February 2022 | Journal article | Biophysical Journal | Read
An In Vivo Fluorescence Resonance Energy Transfer-Based Imaging Platform for Targeted Drug Discovery and Cancer Therapy.
Huang SG, Jiang C, Mughal MJ, Wang GY, Xing FQ
February 2022 | Journal article | Frontiers in Bioengineering and Biotechnology | Read
Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Ragotte RJ, Pulido D, Lias AM, Quinkert D, Alanine DGW, Jamwal A, Davies H, Nacer A, Lowe ED, Grime G, Illingworth J, Donat, RF, Garman EF, Bowyer, PW, Higgins MK, Draper SJ
February 2022 | Journal article | Nature Communications | Read
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex.
Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu XY, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA
January 2022 | Journal article | Science | Read
Ion currents through Kir potassium channels are gated by anionic lipids.
Jin RT, He ST, Black KA, Clarke OB, Wu D, Bolla JR, Johnson P, Periasamy A, Wardak A, Czabotar P, Colman PM, Robinson CV, Laver D, Smith BJ, Gulbis JM
January 2022 | Journal article | Nature Communications | Read
Recent breakthroughs and future directions in drugging aquaporins.
Salman MM, Kitchen P, Yool AJ, Bill RM
January 2022 | Journal article | Trends in Pharmacological Sciences | Read
Molecular basis for redox control by the human cystine/glutamate antiporter system xc.
Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S
December 2021 | Journal article | Nature Communications | Read
Biallelic PI4KA variants cause neurological, intestinal and immunological disease
Salter CG, Cai Y, Lo B, Helman G, Taylor H, McCartney A, Leslie JS, Accogli A, Zara F, Traverso M, Fasham J, Lees JA, Ferla MP, Chioza BA, Wenger O, Scott E, Cross HE, Crawford J, Warshawsky I, Keisling M, Agamanolis D, Melver CW, Cox H, Elawad M, Marton T, Wakeling MN, Holzinger D, Tippelt S, Munteanu M, Valcheva D, Deal C, Van Meerbeke S, Vockley CW, Butte M, Acar U, van der Knaap MS, Korenke GC, Kotzaeridou U, Balla T, Simons C, Uhlig HH, Crosby AH, De Camilli P, Wolf NI, Baple EL
December 2021 | Journal article | Brain | Read
Break-ups and make-ups: DNA search and repair.
Lalande E, El Sayyed H
December 2021 | Journal article | Nature Reviews Microbiology | Read
Multiplexed Profiling of Extracellular Vesicles for Biomarker Development.
Jiang C, Fu Y, Liu G, Shu B, Davis J, Tofaris GK
December 2021 | Journal article | Nano-Micro Letters | Read
Acyl carrier protein promotes MukBEF action in Escherichia coli chromosome organization-segregation.
Prince JP, Bolla JR, Fisher GLM, Mäkelä J, Fournier M, Robinson CV, Arciszewska LK, Sherratt DJ
November 2021 | Journal article | Nature Communications | Read
Single molecule mass photometry reveals the dynamic oligomerization of human and plant peroxiredoxins.
Liebthal M, Kushwah MS, Kukura P, Dietz K-J
November 2021 | Journal article | iScience | Read
Effects of ionic strength on gating and permeation of TREK-2 K2P channels
Conrad LJ, Proks P, Tucker SJ
October 2021 | Journal article | Plos One | Read
Mass spectrometry informs the structure and dynamics of membrane proteins involved in lipid and drug transport.
Bolla JR, Fiorentino F, Robinson CV
October 2021 | Journal article | Current Opinion in Structural Biology | Read
Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target
Adams O, Deme JC, Parker JL, Fowler PW, Lea SM, Newstead S
October 2021 | Journal article | Structure | Read
Structural Basis for Silicic Acid Uptake by Higher Plants.
van den Berg B, Pedebos C, Bolla JR, Robinson CV, Baslé A, Khalid S
September 2021 | Journal article | Journal of Molecular Biology | Read
Molecular basis for redox control by the human cystine/glutamate antiporter System xc-
Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S
August 2021 | Journal article | Read
Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals.
Parker JL, Deme JC, Wu Z, Kuteyi G, Huo J, Owens RJ, Biggin PC, Lea SM, Newstead S
August 2021 | Journal article | Science Advances | Read
The molecular basis of regulation of bacterial capsule assembly by Wzc.
Yang Y, Liu J, Clarke BR, Seidel L, Bolla JR, Ward PN, Zhang P, Robinson CV, Whitfield C, Naismith JH
July 2021 | Journal article | Nature Communications | Read
Structural basis of antifolate recognition and transport by PCFT.
Parker JL, Deme JC, Kuteyi G, Wu Z, Huo J, Goldman ID, Owens RJ, Biggin PC, Lea SM, Newstead S
July 2021 | Journal article | Nature | Read
Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target.
Adams O, Deme JC, Parker JL, CRyPTIC Consortium, Fowler PW, Lea SM, Newstead S
June 2021 | Journal article | Structure | Read
Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons.
Tanudjojo B, Shaikh SS, Fenyi A, Bousset L, Agarwal D, Marsh J, Zois C, Heman-Ackah S, Fischer R, Sims D, Melki R, Tofaris GK
June 2021 | Journal article | Nature Communications | Read
The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase.
Kaur H, Jakob RP, Marzinek JK, Green R, Imai Y, Bolla JR, Agustoni E, Robinson CV, Bond PJ, Lewis K, Maier T, Hiller S
May 2021 | Journal article | Nature | Read
